Related Experiment Video
Updated: Mar 12, 2026
A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
Published on: November 15, 2024
The Association between Impaired Glucose Regulation and Prognosis of Chinese Patients with Intracerebral Hemorrhage
Shichao Sun1, Yuesong Pan2,3, Xingquan Zhao2,4,5,6
1Department of Neurology, The Second Hospital, Hebei Medical University, Shi Jiazhuang, Hebei Province, China.
Insights
Impaired glucose regulation (IGR) significantly increases dependency and poor outcomes one year after intracerebral hemorrhage (ICH) in Chinese patients. However, IGR did not show a significant association with increased mortality in this patient group.
Area of Science:
- Neurology
- Endocrinology
- Public Health
Background:
- Intracerebral hemorrhage (ICH) is a severe neurological condition with significant morbidity and mortality.
- Impaired glucose regulation (IGR), including prediabetes and undiagnosed diabetes, is increasingly recognized as a risk factor in various medical conditions.
- The impact of IGR on long-term outcomes following ICH requires further investigation, particularly in diverse populations.
Purpose of the Study:
- To investigate the influence of impaired glucose regulation (IGR) on 1-year outcomes in patients diagnosed with intracerebral hemorrhage (ICH).
- To determine if IGR is an independent predictor of death, dependency, or poor outcome at one year post-ICH.
- To analyze the specific impact of IGR on different functional outcomes in a Chinese patient cohort.
Main Methods:
- A cohort of 288 non-diabetic patients hospitalized for ICH between 2008 and 2009 across 35 centers in China were consecutively recruited.
- Impaired glucose regulation (IGR) was identified using a standard oral glucose tolerance test performed around day 14 post-stroke or before discharge.
- Cox proportional hazard models and logistic regression models were employed to assess the association between IGR and 1-year outcomes (death, dependency, poor outcome).
Main Results:
- Out of 288 non-diabetic ICH patients, 150 (52.1%) were identified as having IGR.
- IGR was significantly associated with increased 1-year dependency (adjusted OR 2.18, P=0.01) and poor outcome (adjusted OR 2.17, P=0.007).
- No significant association was found between IGR and 1-year mortality (adjusted HR 1.49, P=0.39).
Conclusions:
- Impaired glucose regulation (IGR) is an independent predictor of poor functional outcomes, specifically dependency, at one year following intracerebral hemorrhage (ICH) in Chinese patients.
- The findings suggest that managing glucose dysregulation may be crucial for improving functional recovery after ICH.
- While IGR impacts dependency and overall poor outcomes, its effect on mortality in ICH patients warrants further research.
Abstract:
This study aimed at observing the influence of impaired glucose regulation (IGR) on 1-year outcomes in patients with intracerebral hemorrhage (ICH). Patients hospitalized for ICH from 2008 to 2009 were recruited consecutively at 35 centres across China. A standard oral glucose tolerance test at day 14 ± 3 after stroke onset or before discharge was performed to identify IGR. The outcomes were death (modified Rankin scale [mRS] score of 6), dependency (mRS score of 2 to 5) and poor outcome (mRS score of 2 to 6) at 1 year. Cox proportion hazard model for death and logistic regression model for dependency and poor outcome were performed to investigate the influence of IGR on 1-year outcomes. A total of 288 non-diabetic ICH patients were included in this analysis, among which 150 (52.1%) were IGR. IGR was associated with 1-year dependency (adjusted odds ratio [OR] 2.18, 95% confidence interval [CI], 1.19-3.99; P = 0.01) and poor outcome (adjusted OR 2.17; 95% CI, 1.24-3.80; P = 0.007) of patients with ICH. However, IGR showed no significant association with 1-year death (adjusted hazard ratio 1.49, 95% CI, 0.60-3.67; P = 0.39). IGR was independently associated with 1-year poor outcome of ICH in Chinese patients, with more important influence on dependency than death.
