[Systemic sclerosis : What is currently available for treatment?]

Area of Science:

• Rheumatology
• Immunology
• Vascular Medicine

Background:

• Systemic sclerosis (scleroderma) is a rheumatologic condition characterized by inflammation, autoimmunity, tissue fibrosis, and vascular lesions.
• Current therapeutic strategies are guided by organ involvement, addressing vascular and fibrotic aspects beyond immunosuppression.

Purpose of the Study:

• To review the current treatment options for systemic sclerosis.
• To highlight the evolving therapeutic landscape over the past decade.

Main Methods:

• Literature review of available treatment options for systemic sclerosis.
• Analysis of recent advancements in managing vascular complications.
• Assessment of current approaches to fibrotic disease features.

Main Results:

• Treatment for systemic sclerosis is multifaceted, addressing inflammation, autoimmunity, fibrosis, and vascular complications.
• Significant advancements have been made in treating vascular complications in recent years.
• Effective treatments for fibrotic features remain a significant challenge.

Conclusions:

• Therapeutic approaches for systemic sclerosis are evolving, with a focus on organ-specific treatments.
• The management of fibrotic manifestations requires further development.
• Future treatment options are expected to continue advancing.