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Related Experiment Video

Updated: Mar 12, 2026

A Data-Driven Approach to Quantifying Immune States in Sepsis
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Lymphocyte integrin expression differences between SIRS and sepsis patients.

D S Heffernan1, S F Monaghan2, Alfred Ayala2

  • 1Division of Surgical Research, Department of Surgery, Warren Alpert Medical School of Brown UniversityRhode Island Hospital, 211 Aldrich Building, 593 Eddy Street, Providence, 02903, RI, USA. DHeffernan@Brown.edu.

Irish Journal of Medical Science
|November 1, 2016
PubMed
Summary
This summary is machine-generated.

T-cell integrin expression differs between Systemic Inflammatory Response Syndrome (SIRS) and sepsis. CD29 (β1 integrin) is lowest in SIRS, while CD18 (β2 integrin) is ubiquitous, with variations based on sepsis source.

Keywords:
Integrin expressionLymphocyteSepsis

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Area of Science:

  • Immunology
  • Critical Care Medicine

Background:

  • Systemic Inflammatory Response Syndrome (SIRS) and sepsis are major causes of mortality.
  • T-lymphocytes are crucial in SIRS and sepsis pathogenesis and outcomes.
  • Integrins, such as β1 (CD29) and β2 (CD18), are vital for lymphocyte function and infection clearance.

Purpose of the Study:

  • To investigate disruptions in T-cell integrin expression (CD29 and CD18) in SIRS and sepsis.
  • To compare integrin expression patterns between SIRS and sepsis patients.

Main Methods:

  • T-lymphocytes were isolated from ICU patients diagnosed with SIRS or sepsis.
  • Flow cytometry was used to analyze CD18 (β2) and CD29 (β1) expression on CD3+ T cells.
  • Septic patients were categorized by the source of infection (abdominal vs. non-abdominal).

Main Results:

  • CD18 (β2 integrin) showed ubiquitous expression on T-cells across all groups.
  • CD29 (β1 integrin) expression was significantly lower in SIRS patients (20.4%) compared to septic patients (35.5%) and healthy volunteers (54.1%).
  • Septic patients with abdominal sources exhibited higher CD29 expression (41.7%) than those with non-abdominal sources (29.5%).

Conclusions:

  • Significant differences in T-cell integrin expression distinguish SIRS from sepsis.
  • The source of sepsis influences T-cell integrin expression patterns.
  • Further research is required to elucidate the causal relationship between SIRS, sepsis, and T-cell integrin expression.