Related Experiment Video
Updated: Mar 12, 2026

The Use of Chemostats in Microbial Systems Biology
Published on: October 14, 2013
Product-Form Stationary Distributions for Deficiency Zero Networks with Non-mass Action Kinetics
David F Anderson1, Simon L Cotter2
1Department of Mathematics, University of Wisconsin, Madison, WI, USA.
Abstract:
In many applications, for example when computing statistics of fast subsystems in a multiscale setting, we wish to find the stationary distributions of systems of continuous-time Markov chains. Here we present a class of models that appears naturally in certain averaging approaches whose stationary distributions can be computed explicitly. In particular, we study continuous-time Markov chain models for biochemical interaction systems with non-mass action kinetics whose network satisfies a certain constraint. Analogous with previous related results, the distributions can be written in product form.
Related Concept Videos
The Nernst Equation
The interconnection between standard cell potentials and various thermodynamic parameters such as the standard free energy change ΔG° and equilibrium constant K has been previously explored. For example, a redox reaction involving zinc(II) and tin(II) ions at 1 M concentration with Eºcell = +0.291 V and ΔG° = −56.2 kJ is spontaneous.
Drug Distribution as One-Compartment Model and Elimination by Nonlinear Pharmacokinetics: Overview
For instance, consider the metabolism of sodium salicylate. This compound is metabolized into two distinct substances: a glucuronide and a glycine conjugate. The rate of conjugation depends...
Elimination Kinetics: First-Order and Zero-Order
Drug clearance depends on the rate of drug elimination and its plasma concentration. Another important parameter is a drug's half-life, which is the time required for its concentration to decrease by half. In most cases, drug clearance follows first-order...
Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model
When a drug is administered through a constant intravenous infusion and eliminated via nonlinear pharmacokinetics, it follows zero-order input. For example, oral drugs undergo first-order absorption upon administration and are eliminated through nonlinear pharmacokinetics.
In the case of subcutaneously administered drugs,...
Nonlinear Pharmacokinetics: Michaelis-Menten Equation
Vmax represents the maximum achievable process rate, while KM, known as the Michaelis constant, signifies the drug concentration at which the process rate reaches half its maximum. This relationship between Vmax, KM, and Cp gives rise to three distinct...
Free Energy Changes for Nonstandard States

