Diagnostic performance of noninvasive fractional flow reserve derived from coronary computed tomography angiography in ischemia-causing coronary stenosis: a meta-analysis
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Updated: Mar 12, 2026
Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats
Published on: June 28, 2019
Aimin Ding1, Guoqing Qiu2, Wensheng Lin2
1The Second Medical Imaging Department of the First People's Hospital of Fuzhou, Jiangxi Province, No. 421 Gan Dong Avenue, Lin Chuan District, Fuzhou, Jiangxi, 344100, China. 5413dam@163.com.
Purpose:
Fractional flow reserve based on coronary computed tomographic angiography (CCTA; FFRCT) can evaluate functional severity in coronary artery disease (CAD). This study investigated the diagnostic value of FFRCT for determining CAD severity.
Materials And Methods:
Medline, Cochrane, EMBASE, and Google Scholar databases were searched until June 16, 2016 using the following search terms: fractional flow reserve, coronary computed tomography angiography, myocardial ischemia. Randomized controlled trials, two-arm prospective studies, and retrospective studies were included in the analysis.
Results:
Twenty-one studies were included with a total of 2216 subjects and 2798 vessels. FFRCT, sensitivity per-vessel and per-patient were ≥82% and specificity was ≥73% for diagnosis of ischemia. FFRCT had better diagnostic accuracy and discrimination than CCTA.
Conclusion:
This study indicates that FFRCT may be a good tool for screening and diagnosing of myocardial ischemia in patients with CAD.
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