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Anxiety and Cardiovascular Disease Risk: a Review
Phillip J Tully1,2,3, Nathan J Harrison4,5, Peter Cheung5
1Bordeaux Population Health, University of Bordeaux, U1219, Bordeaux, France. phillip.tully@adelaide.edu.au.
Insights
Unrecognized anxiety is a significant challenge in cardiology, increasing cardiovascular disease (CVD) risk and worsening prognosis. Early identification and treatment of anxiety are crucial for better patient outcomes and heart health.
Area of Science:
- Cardiology and Psychiatry
- Psychocardiology
- Clinical Medicine
Background:
- Anxiety is frequently unrecognized in cardiology, leading to frequent emergency visits and extensive testing for cardiovascular disease (CVD).
- Anxiety disorders are increasingly linked to the onset and progression of CVD, though causality is not yet established.
- Anxiety independently predicts poor outcomes in patients with existing CVD, separate from depression.
Purpose of the Study:
- To review the relationship between anxiety and cardiovascular disease (CVD).
- To describe methods for identifying and treating anxiety in cardiac patients.
- To explore potential mechanisms linking anxiety to heart disease (cardiogenesis).
Main Methods:
- Literature review focusing on anxiety, its subtypes, and cardiovascular disease (CVD).
- Analysis of emerging research on anxiety disorders and CVD risk.
- Examination of potential pathways for anxiety-induced heart disease.
Main Results:
- Anxiety disorders are associated with an increased risk of developing CVD.
- Anxiety negatively impacts prognosis in individuals with established CVD, independent of depression.
- Guidelines for identifying and managing anxiety in cardiac settings are needed.
Conclusions:
- Anxiety requires greater clinical and research attention, similar to depression.
- Understanding anxiety's role is vital for developing new treatments for heart disease.
- Interventions targeting anxiety can benefit individuals at risk for or with existing CVD.
Abstract:
Unrecognized anxiety is a difficult clinical presentation in cardiology. Anxiety leads to recurring emergency department visits and the need for numerous diagnostic evaluations to rule out cardiovascular disease (CVD). This review focuses broadly on anxiety and its subtypes in relation to the onset and progression of CVD while describing helpful guidelines to better identify and treat anxiety. Potential mechanisms of cardiopathogenesis are also described. An emerging literature demonstrates that anxiety disorders increase the risk for incident CVD but a causal relationship has not been demonstrated. Anxiety portends adverse prognosis in persons with established CVD that is independent from depression. The level of clinical priority received by depression should be extended to research and clinical intervention efforts in anxiety. Anxiety holds direct relevance for uncovering mechanisms of cardiopathogenesis, developing novel therapeutic strategies, and initiating clinical interventions in the population at risk of developing heart disease, or those already diagnosed with CVD.
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