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Nanogold-Gallate Chitosan-Targeted Pulmonary Delivery for Treatment of Lung Cancer
Seamkwan Komenek1, Urarika Luesakul1, Sanong Ekgasit1
1Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
Abstract:
Lung cancer is one of the most of cancer type founds and a leading cause of death worldwide. Through the development of new candidate compound (3,4,5-tribenzyloxybenzoic acid (GAOBn)) and a drug delivery system of our design of quaternized chitosan-gallic acid-folic acid stabilized gold nanoparticles (Au@QCS-GA-FA) as the targeted nanocarrier for treatment of lung cancer, we have found that GAOBn not only showed high cytotoxicity against lung cancer cells (CHAGO) with more than tenfold than cisplatin, but also showed low toxicity against normal cells (CRL-1947). The combination Au@QCS-GA-FA/GAOBn showed highly efficient cellular uptake and localization of gold nanoparticles via the active targeting of cancer cells. This established the potential of Au@QCS-GA-FA as a nanocarrier for anticancer agent-targeted delivery for treatment of lung cancer.
Insights
A novel compound (GAOBn) demonstrated superior lung cancer cell killing ability compared to cisplatin with minimal toxicity to normal cells. A targeted nanocarrier (Au@QCS-GA-FA) enhanced drug delivery and localization for effective lung cancer treatment.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Lung cancer remains a leading global cause of cancer-related mortality.
- Developing targeted drug delivery systems is crucial for improving treatment efficacy and reducing side effects.
- Novel compounds with high cancer cell cytotoxicity and low normal cell toxicity are needed.
Purpose of the Study:
- To synthesize and evaluate a new compound, 3,4,5-tribenzyloxybenzoic acid (GAOBn), for its anti-lung cancer properties.
- To develop a targeted nanocarrier, quaternized chitosan-gallic acid-folic acid stabilized gold nanoparticles (Au@QCS-GA-FA), for delivering GAOBn to lung cancer cells.
- To assess the efficacy and targeting capability of the Au@QCS-GA-FA/GAOBn combination for lung cancer treatment.
Main Methods:
- Synthesis and characterization of GAOBn and the Au@QCS-GA-FA nanocarrier.
- In vitro cytotoxicity assays of GAOBn against lung cancer cells (CHAGO) and normal cells (CRL-1947).
- Evaluation of cellular uptake and localization of Au@QCS-GA-FA/GAOBn in cancer cells.
Main Results:
- GAOBn exhibited significantly higher cytotoxicity against lung cancer cells (over tenfold) compared to cisplatin.
- GAOBn demonstrated low toxicity towards normal cells.
- The Au@QCS-GA-FA nanocarrier facilitated efficient cellular uptake and targeted localization of the gold nanoparticles within cancer cells.
Conclusions:
- GAOBn is a potent cytotoxic agent against lung cancer cells with a favorable safety profile.
- Au@QCS-GA-FA serves as an effective nanocarrier for targeted delivery of anticancer agents.
- The Au@QCS-GA-FA/GAOBn system shows significant potential for targeted lung cancer therapy.
