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Related Experiment Videos

Immunocytochemical localization of the terminal complement complex in multiple sclerosis.

D A Compston1, B P Morgan, A K Campbell

  • 1Department of Neurology, University of Wales College of Medicine, Heath Park, Cardiff.

Neuropathology and Applied Neurobiology
|July 1, 1989
PubMed
Summary

Complement system activation, indicated by C9 deposits, is observed in multiple sclerosis (MS) brain tissue. This suggests a role for complement in the immune-mediated tissue damage characteristic of MS.

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Area of Science:

  • Neurology
  • Immunology
  • Pathology

Background:

  • Multiple sclerosis (MS) is a chronic inflammatory disease affecting the central nervous system.
  • The pathogenesis of MS involves complex interactions between immune cells, inflammatory mediators, and the blood-brain barrier.
  • The role of the complement system in MS pathogenesis remains an area of active investigation.

Purpose of the Study:

  • To investigate the presence and localization of complement system components in MS brain tissue.
  • To determine if complement activation is associated with focal tissue damage in MS plaques.

Main Methods:

  • Immunocytochemical analysis of post-mortem brain tissue from MS patients and controls.
  • Detection of C9 and the terminal complement complex.

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  • Association of deposits with capillary endothelial cells within plaques and white matter.

    • Main Results:

    • Granular deposits of C9 and the terminal complement complex (0.3-1.2 microns) were found in 5/7 MS patients and one patient with subacute sclerosing panencephalitis.
    • These deposits were associated with capillary endothelial cells, predominantly in plaques and adjacent white matter.
    • No such deposits were observed in control individuals (7/7).

    Conclusions:

    • The findings suggest that complement activation occurs in the context of MS.
    • Complement activation may be involved in the focal tissue damage observed in MS.
    • This process may involve the passage of immune mediators across the blood-brain barrier.