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[Radioisotopic angiographic study of left ventricular function in hypertensive disease]
Insights
Essential arterial hypertension impairs left ventricular function, reducing ejection fraction (EF) and peak filling rates (PFR). Older hypertensive patients showed more significant PFR reduction, indicating diastolic filling abnormalities.
Area of Science:
- Cardiology
- Cardiovascular Physiology
- Hypertension Research
Background:
- Essential arterial hypertension is a prevalent condition affecting cardiovascular health.
- Left ventricular dysfunction is a known complication of long-standing hypertension.
- Early detection of diastolic dysfunction is crucial for managing hypertensive heart disease.
Purpose of the Study:
- To assess left ventricular function in patients with essential arterial hypertension.
- To compare cardiac function parameters between hypertensive patients and normal subjects.
- To investigate the impact of age on ventricular function in hypertension.
Main Methods:
- Gated radionuclide ventriculography was employed to evaluate cardiac function.
- Left ventricular ejection fraction (EF) and peak filling rate (PFR) were measured.
- Hypertensive patients were compared with a control group of normal subjects.
Main Results:
- Hypertensive patients exhibited reduced ejection fraction (EF) and peak filling rates (PFR).
- Even hypertensive patients with normal EF showed significantly reduced PFR.
- Older hypertensive individuals displayed more pronounced reductions in PFR, indicating impaired diastolic filling.
Conclusions:
- Peak filling rate (PFR) is a sensitive indicator of ventricular dysfunction in hypertension.
- Arterial hypertension, particularly in older individuals, exacerbates diastolic filling abnormalities.
- Hypertension and advanced age synergistically worsen ventricular diastolic function, especially in hypertrophic heart disease.
Abstract:
The aim of this study was to evaluate left ventricular function in 26 patients with essential arterial hypertension, compared with 33 normal subjects, using gated radionuclide ventriculography. The hypertensive patients had reduced values of ventricular ejection fraction (EF), peak ejection and peak filling (PRF) rates. A group of 10 hypertensive patients with normal EF, showed significantly reduced values of PFR, as compared to normal subjects. The older hypertensive patients had significantly reduced PRF values, compared to younger patients. PFR is a more sensitive index in evaluating the impairment of ventricular function in patients with hypertension, though it lacks real discriminating diagnostic value. In hypertrophic heart disease the association between arterial hypertension and old age contributed to accentuate the abnormality in ventricular diastolic filling.