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Assessment of Diastolic Function in Hypertrophic Cardiomyopathy by Computed Tomography-Derived Analysis of Left

Itai Ghersin1, Eduard Ghersin, Sobhi Abadi

  • 1From the *Technion-Israel Institute of Technology, Haifa, Israel; †Department of Radiology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL; ‡Medical Imaging Department and §Cardiology Department, Rambam Health Care Campus, Haifa, Israel; and ∥Department of Cardiology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL.

Journal of Computer Assisted Tomography
|November 1, 2016
PubMed

Insights

Cardiac computed tomography can assess diastolic dysfunction in hypertrophic cardiomyopathy (HCM). Simultaneous left ventricular (LV) and left atrial (LA) volume changes reveal impaired LA function and compensatory LV filling, indicating increased pulmonary pressure.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Physiology

Background:

  • Hypertrophic cardiomyopathy (HCM) presents with diastolic dysfunction, posing challenges for noninvasive assessment.
  • Diastolic dysfunction significantly impacts cardiac function and patient prognosis.

Purpose of the Study:

  • To evaluate the utility of cardiac computed tomography (CT) in assessing diastolic function in HCM patients.
  • To investigate simultaneous left ventricular (LV) and left atrial (LA) volume changes as a measure of diastolic function.

Main Methods:

  • A study involving 21 HCM patients and 21 age-matched controls.
  • Cardiac CT was used to calculate LV and LA volumes.
  • Derived early and late diastolic volume changes for analysis.

Main Results:

  • HCM patients exhibited significantly larger LA volumes and reduced LA total emptying fraction compared to controls (30 ± 7% vs 42 ± 6%).
  • Conduit volume was increased in HCM patients (30 ± 6 vs 22 ± 4 mL/m), contributing a higher proportion to LV diastolic filling.
  • This suggests compensatory LV passive filling due to LA dysfunction, potentially increasing pulmonary filling pressures.

Conclusions:

  • Simultaneous CT-derived LV and LA volume changes effectively characterize diastolic dysfunction in HCM.
  • This imaging approach offers a novel method for assessing diastolic function in HCM.
Abstract

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