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Effect of Marijuana Use on Thyroid Function and Autoimmunity.

Sonali Malhotra1, Rubina A Heptulla2, Peter Homel3

  • 11 Pediatric Endocrinology, Infant and Children's Hospital of Brooklyn, Maimonides Medical Center , Brooklyn, New York.

Thyroid : Official Journal of the American Thyroid Association
|November 5, 2016
PubMed
Summary
This summary is machine-generated.

Recent marijuana use is linked to lower thyroid-stimulating hormone (TSH) levels but not thyroid dysfunction. This study explored cannabis effects on thyroid health in adults.

Keywords:
TSHautoimmune thyroiditishypothyroidismmarijuana

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Area of Science:

  • Endocrinology
  • Public Health
  • Pharmacology

Background:

  • Marijuana legalization is expanding for medical and recreational use.
  • The impact of marijuana on thyroid function and autoimmunity remains largely unknown.
  • Understanding these effects is crucial given increasing cannabis consumption.

Purpose of the Study:

  • To investigate the association between marijuana use and thyroid parameters.
  • To assess the relationship between cannabis consumption and thyroid autoimmunity.
  • To analyze the effects of recent marijuana use on thyroid function in adults.

Main Methods:

  • Cross-sectional analysis of National Health and Nutrition Examination Survey (NHANES) data (2007-2012).
  • Included 5280 adults (18-69 years) with marijuana use and thyroid lab results.
  • Categorized participants into nonusers, past users, and recent users; compared outcomes using logistic regression.

Main Results:

  • 15% of participants were recent marijuana users.
  • Recent users showed a significantly lower frequency of elevated thyrotropin (TSH) and positive anti-thyroperoxidase antibody (TPOAb).
  • Recent marijuana use predicted lower TSH levels (OR 0.344, p=0.04) but not negative TPOAb after controlling for confounders.

Conclusions:

  • Recent marijuana use is associated with lower TSH levels.
  • No significant association was found between recent marijuana use and thyroid dysfunction.
  • Further research is needed to elucidate the mechanisms behind these observed associations.