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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

339
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
339
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

307
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
307
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

307
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
307
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

785
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
785
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

302
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
302
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

291
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
291

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Related Experiment Video

Updated: Mar 12, 2026

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit
06:52

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

Published on: September 30, 2020

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Factors affecting medication adherence in elderly people.

Hyekyung Jin1, Yeonhee Kim2, Sandy Jeong Rhie3

  • 1College of Pharmacy.

Patient Preference and Adherence
|November 2, 2016
PubMed
Summary

Medication adherence in older adults is influenced by factors like education and health issues, not functional health literacy. Pharmacists should focus on patient counseling and satisfaction to improve adherence.

Keywords:
ARMSelderlyhealth literacymedication adherence

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Oral Health Assessment by Lay Personnel for Older Adults
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Last Updated: Mar 12, 2026

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit
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Oral Health Assessment by Lay Personnel for Older Adults
08:47

Oral Health Assessment by Lay Personnel for Older Adults

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Area of Science:

  • Gerontology
  • Health Literacy
  • Pharmacology

Background:

  • Functional health literacy (FHL) in elderly patients and its impact on medication adherence is poorly understood.
  • This study aimed to assess FHL in older adults and identify predictors of medication adherence.

Purpose of the Study:

  • To examine functional health literacy (FHL) among elderly patients.
  • To identify factors influencing medication adherence in this population.

Main Methods:

  • A cross-sectional survey was conducted with 160 participants aged 65+.
  • Functional health literacy was assessed using the Korean Functional Health Literacy Test.
  • Medication adherence was measured using the Adherence to Refills and Medication Scale.

Main Results:

  • 52.5% of participants exhibited low medication adherence.
  • Key factors influencing adherence included satisfaction with service, medication counseling explanation, education level, health problems, and dosing frequency.
  • No significant association was found between FHL and medication adherence.

Conclusions:

  • Medication adherence in elderly patients is linked to education, health status, dosing, and counseling quality, not FHL.
  • Pharmacists should tailor counseling based on individual patient characteristics and ensure satisfaction to enhance adherence.