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Related Experiment Videos

Cleidocranial dysplasia: a light microscope, electron microscope, and crystallographic study.

H Yamamoto1, T Sakae, J E Davies

  • 1Department of Oral Pathology, Nihon University School of Dentistry at Matsudo, Chiba, Japan.

Oral Surgery, Oral Medicine, and Oral Pathology
|August 1, 1989
PubMed
Summary

This study details a rare case of cleidocranial dysplasia with over 60 unerupted teeth, revealing enamel hypoplasia but normal crystal structure. It explores causes for eruption failure and supernumerary teeth in this condition.

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Area of Science:

  • Dentistry
  • Genetics
  • Pathology

Background:

  • Cleidocranial dysplasia (CCD) is a rare genetic disorder affecting bone development, particularly the clavicles and skull.
  • Dental anomalies, including unerupted and supernumerary teeth, are common in CCD but the underlying mechanisms require further investigation.

Observation:

  • This report details an unusual case of cleidocranial dysplasia in a patient presenting with over 60 unerupted teeth.
  • The patient exhibited pseudoprognathism and facial asymmetry, with the right side of the face being larger than the left.
  • Microscopic examination included light microscopy and scanning electron microscopy (SEM).

Findings:

  • Extracted teeth demonstrated enamel hypoplasia when analyzed with light and scanning electron microscopy.

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  • Crystallographic techniques revealed that the crystalline composition of the enamel was comparable to that of normal teeth.
  • Despite enamel hypoplasia, the crystalline structure did not appear to be the primary cause of the lack of tooth eruption.

    • Implications:

    • This case highlights the complex dental manifestations of cleidocranial dysplasia.
    • Understanding the microscopic and crystalline properties of teeth in CCD can aid in diagnosing and managing these anomalies.
    • Further research into the pathogenesis of unerupted and supernumerary teeth in CCD is warranted to explore potential therapeutic strategies.