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In vitro antimicrobial susceptibility patterns of Propionibacterium acnes isolated from patients with acne vulgaris

Indu Biswal1, Rajni Gaind, Neeraj Kumar

  • 1Vardhman Mahavir Medical College and Safdarjang Hospital, New Delhi, India. drindubiswal@gmail.com.

Journal of Infection in Developing Countries
|November 2, 2016
PubMed
Abstract

Insights

This study investigated antibiotic resistance in Propionibacterium acnes, a key factor in acne vulgaris. Findings reveal significant resistance to common antibiotics, highlighting the need for new treatment strategies.

Area of Science:

  • Microbiology
  • Dermatology
  • Antimicrobial Resistance

Background:

  • Propionibacterium acnes is linked to acne vulgaris development.
  • Widespread antibiotic use for acne has increased P. acnes resistance.
  • Understanding current resistance patterns is crucial for effective treatment.

Purpose of the Study:

  • To determine the antibiotic resistance profiles of P. acnes isolated from acne lesions.
  • To assess resistance to penicillin, erythromycin, clindamycin, ciprofloxacin, nadifloxacin, and tetracycline.
  • To evaluate the minimum inhibitory concentration (MIC) of minocycline.

Main Methods:

  • 102 samples from acne lesions were cultured.
  • Species identification used conventional methods and VITEK2 Compact.
  • Antibiotic susceptibility testing included E-test and agar dilution, interpreted using EUCAST and CLSI guidelines.

Main Results:

  • P. acnes was the most common anaerobe (66%).
  • Resistance rates varied: erythromycin (10.6%/6.1%), clindamycin (7.6%/0%), minocycline (7.8%/0%), and tetracycline (9.2%).
  • Nadifloxacin and minocycline showed lower MIC values compared to ciprofloxacin and tetracycline.

Conclusions:

  • This is the first study on P. acnes antibiotic resistance in India.
  • Findings underscore the growing challenge of antibiotic resistance in acne treatment.
  • Further research into novel therapeutic approaches is warranted.

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