Related Experiment Video
Updated: Mar 12, 2026

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats
Published on: June 28, 2019
Coronary Fistula and Myocardial Ischemia: What is the Relationship?
Ashish H Shah, Robert J Cusimano, Maral Ouzounian1
1Toronto General Hospital, 585 University Avenue, Toronto, ON, M5G 2N2 Canada. maral.ouzounian@uhn.ca.
Insights
A rare coronary artery fistula caused myocardial ischemia. Ligating this fistula led to heart failure, but restoring flow improved the patient, highlighting the fistula's critical role.
Area of Science:
- Cardiology
- Vascular Surgery
- Anatomical Anomalies
Background:
- Coronary artery fistulas are uncommon congenital abnormalities.
- Large fistulas can cause myocardial ischemia due to coronary steal.
- This case explores a fistula's role in a patient with severe coronary artery disease.
Observation:
- A 73-year-old male presented with exertional angina.
- Imaging revealed severe coronary artery disease and a large coronary artery fistula.
- Initial fistula ligation caused right ventricular failure and cardiogenic shock.
Findings:
- Reestablishing fistula flow led to patient recovery.
- The fistula likely became a critical nutritive vessel due to ischemia-induced angiogenesis.
- This highlights the fistula's importance even after coronary revascularization.
Implications:
- Coronary fistulas, even when large, can serve vital nutritive functions.
- This case is the first to report the critical nutritive value of a coronary fistula.
- Understanding this role is crucial for managing patients with coronary artery fistulas and concomitant coronary artery disease.
Abstract:
Coronary artery fistula is a rare anomaly; large fistulae may result in myocardial ischemia from coronary steal. We present the case of a 73-year-old male who presented with exertional angina; imaging demonstrated severe coronary artery disease and a large coronary artery fistula. Ligation of the fistula resulted in severe right ventricular failure and cardiogenic shock. After reestablishing flow to the fistula, the patient recovered. We speculate that the ischemia-induced angiogenesis from the congenitally present fistula made what may have otherwise been an innocent fistula into an important nutritive supply, which remained important despite distal revascularization. To our knowledge, this is the first report describing the critical nutritive value of a coronary fistula.
Related Concept Videos
Coronary Circulation
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
Coronary Artery Disease II: Pathophysiology
Ischemic Heart Disease: Overview
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
Physiology of the Heart: The Cardiac Cycle
Diastole: The Relaxation Phase
During diastole, all four heart chambers relax. The atrioventricular (AV) valves open, and the semilunar valves close. This phase sees the lowest chamber pressures, promoting ventricular filling. Venous blood enters the heart through the...
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
Myocarditis I: Introduction

