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Myasthenia Gravis: Overview and Treatment01:20

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Related Experiment Video

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The Gas6/TAM System and Multiple Sclerosis.

Mattia Bellan1,2,3, Mario Pirisi4,5,6, Pier Paolo Sainaghi7,8

  • 1Department of Translational Medicine, Università del Piemonte Orientale, UPO, via Solaroli 17, 28100 Novara, Italy. bellanmattia@yahoo.it.

International Journal of Molecular Sciences
|November 2, 2016
PubMed
Summary
This summary is machine-generated.

Growth arrest specific 6 (Gas6) and its receptors (TAM) regulate immune responses. Emerging evidence suggests their involvement in neuroinflammation and multiple sclerosis (MS) pathogenesis.

Keywords:
AxlGas6MerTKTAM receptorsTyro3multiple sclerosis

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Area of Science:

  • Immunology
  • Neuroscience
  • Molecular Biology

Background:

  • Growth arrest specific 6 (Gas6) is a protein that interacts with TAM receptors (Tyro3, Axl, MerTK).
  • The Gas6/TAM system influences immune response, inflammation, coagulation, cell growth, and apoptotic cell clearance.
  • Recent research links Gas6 and TAM receptors to neuroinflammation and multiple sclerosis (MS).

Purpose of the Study:

  • To review the biology of the Gas6/TAM system.
  • To examine the evidence linking Gas6/TAM to multiple sclerosis pathogenesis.

Main Methods:

  • Literature review of existing studies on Gas6, TAM receptors, and multiple sclerosis.

Main Results:

  • The Gas6/TAM system plays diverse biological roles, including immune modulation.
  • Growing evidence suggests a role for Gas6 and TAM receptors in the inflammatory processes underlying MS.

Conclusions:

  • The Gas6/TAM system is a significant factor in immune regulation.
  • Further investigation into the Gas6/TAM system's role in MS pathogenesis is warranted.