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The Gas6/TAM System and Multiple Sclerosis
Mattia Bellan1,2,3, Mario Pirisi4,5,6, Pier Paolo Sainaghi7,8
1Department of Translational Medicine, Università del Piemonte Orientale, UPO, via Solaroli 17, 28100 Novara, Italy. bellanmattia@yahoo.it.
Abstract:
Growth arrest specific 6 (Gas6) is a multimodular circulating protein, the biological actions of which are mediated by the interaction with three transmembrane tyrosine kinase receptors: Tyro3, Axl, and MerTK, collectively named TAM. Over the last few decades, many progresses have been done in the understanding of the biological activities of this highly pleiotropic system, which plays a role in the regulation of immune response, inflammation, coagulation, cell growth, and clearance of apoptotic bodies. Recent findings have further related Gas6 and TAM receptors to neuroinflammation in general and, specifically, to multiple sclerosis (MS). In this paper, we review the biology of the Gas6/TAM system and the current evidence supporting its potential role in the pathogenesis of MS.
Insights
Growth arrest specific 6 (Gas6) and its receptors (TAM) regulate immune responses. Emerging evidence suggests their involvement in neuroinflammation and multiple sclerosis (MS) pathogenesis.
Area of Science:
- Immunology
- Neuroscience
- Molecular Biology
Background:
- Growth arrest specific 6 (Gas6) is a protein that interacts with TAM receptors (Tyro3, Axl, MerTK).
- The Gas6/TAM system influences immune response, inflammation, coagulation, cell growth, and apoptotic cell clearance.
- Recent research links Gas6 and TAM receptors to neuroinflammation and multiple sclerosis (MS).
Purpose of the Study:
- To review the biology of the Gas6/TAM system.
- To examine the evidence linking Gas6/TAM to multiple sclerosis pathogenesis.
Main Methods:
- Literature review of existing studies on Gas6, TAM receptors, and multiple sclerosis.
Main Results:
- The Gas6/TAM system plays diverse biological roles, including immune modulation.
- Growing evidence suggests a role for Gas6 and TAM receptors in the inflammatory processes underlying MS.
Conclusions:
- The Gas6/TAM system is a significant factor in immune regulation.
- Further investigation into the Gas6/TAM system's role in MS pathogenesis is warranted.
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