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Changes in vasomotion pattern and local arteriolar resistance during stepwise pressure reduction.

H H Oude Vrielink¹, D W Slaaf, G J Tangelder

¹Department of Physiology, University of Limburg, Maastricht, The Netherlands.

Pflugers Archiv : European Journal of Physiology

|September 1, 1989

Summary

Vasomotion in arterioles significantly impacts blood flow regulation, especially in smaller side branches. Changes in vasomotion parameters during reduced arterial pressure were observed, influencing local resistance and flow dynamics.

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Area of Science:

Physiology
Cardiovascular Research
Microcirculation

Background:

Arteriolar vasomotion plays a crucial role in regulating local blood flow and resistance.
Understanding the dynamics of vasomotion under varying physiological conditions is essential for comprehending microcirculatory control.

Purpose of the Study:

To investigate changes in vasomotion parameters in transverse arterioles and their side branches during stepwise reduction of arterial pressure.
To assess the influence of vasomotion on local arteriolar resistance and flow dynamics in the tenuissimus muscle.

Main Methods:

Intravital microscopy was employed in urethane-anesthetized rabbits.
Stepwise reduction of arterial pressure was performed.
Effective vascular diameter was calculated to assess flow-carrying capacity.

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Main Results:

Vasomotion's contribution to resistance is limited in main transverse arterioles but significant in first-order side branches.
Reduced arterial pressure led to increased vasomotion cycle length and amplitude.
Effective arteriolar diameter increased, while local blood flow and velocity decreased.
Flow autoregulation was observed in 70% of arterioles.

Conclusions:

Vasomotion is a critical determinant of flow fluctuations in downstream capillaries, particularly in first-order side branches.
Changes in vasomotion parameters during pressure reduction are complex and not solely attributable to single variables like blood flow or pressure.
Further research is needed to elucidate the multifactorial control mechanisms governing vasomotion dynamics.