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Bipolar Disorder and Frontotemporal Dementia: An Intriguing Association
Apostolos Papazacharias1, Madia Lozupone2, Maria Rosaria Barulli3
1Department of Basic Medical Science, Neuroscience and Sense Organs, Psychiatric Unit, University of Bari "Aldo Moro", Bari, Italy.
Journal of Alzheimer'S Disease : JAD
|November 2, 2016
Summary
Bipolar disorder may precede frontotemporal dementia. Two lifelong bipolar disorder patients developed early frontotemporal dementia, suggesting a potential link requiring further investigation.
Area of Science:
- Neuroscience
- Neurology
- Psychiatry
Background:
- Bipolar disorder (BD) is a mood disorder characterized by alternating periods of mania and depression.
- Frontotemporal dementia (FTD) is a group of progressive neurodegenerative disorders affecting the frontal and temporal lobes.
- The relationship between BD and FTD remains an area of active research.
Observation:
- Two patients with lifelong BD experienced a progressive decline in cognitive functions, behavior, and neurological signs.
- These patients received early diagnoses of FTD before age 60.
- One patient was diagnosed with primary progressive aphasia, and the other with FTD with parkinsonism.
Findings:
- The cases suggest that BD might serve as a prodromal state for FTD.
- Unexpected cognitive and behavioral decline in BD patients warrants consideration for FTD diagnosis.
- Early FTD diagnosis in BD patients highlights a potential overlapping pathology.
Implications:
- Considering FTD in patients with a history of BD and cognitive decline is crucial.
- Further research involving genetic, neuropsychological, and neuroimaging markers is needed.
- Understanding the BD-FTD association may reveal new therapeutic strategies.
Keywords:
Bipolar disorderbehavioral declinecognitive impairmentfrontotemporal dementiaparkinsonismprimary progressive aphasiaMore Related Videos
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