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Related Concept Videos

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

Nociception

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.

Types of RNA

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...

Types of RNA

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...

Neural Regulation

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

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Related Experiment Video

Updated: Mar 12, 2026

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

Published on: July 16, 2014

Emerging Putative Associations between Non-Coding RNAs and Protein-Coding Genes in Neuropathic Pain: Added Value from

Hemalatha B Raju¹, Nicholas F Tsinoremas², Enrico Capobianco³

¹Center for Computational Science, University of Miami Miller School of Medicine, Miami, FL, USA; Human Genetics and Genomic Graduate Program, University of Miami Miller School of Medicine, Miami, FL, USA.

Frontiers in Neurology

|November 3, 2016

Summary

This study reveals the significant role of non-coding RNAs (ncRNAs) in nerve regeneration after injury. By repurposing microarray data, researchers identified differentially expressed ncRNAs and their protein targets, offering new insights into neuropathic pain mechanisms.

Keywords:

differential expression microarray data reuse networks neuropathic pain non-coding RNAs pathway analysis time-course profiling

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Last Updated: Mar 12, 2026

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

Published on: July 16, 2014

Cell Subtype-specific Analysis of Neuronal Membrane Proteasome in Somatosensory Neurons

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Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies

Published on: October 6, 2022

Area of Science:

Neuroscience
Genomics
Bioinformatics

Background:

Nerve regeneration differs between the peripheral and central nervous systems.
The role of non-coding RNAs (ncRNAs) in nerve regeneration is largely unknown.
Limited human neuropathic pain (NP) data necessitates novel analytical approaches.

Purpose of the Study:

To investigate the role of ncRNAs in nerve regeneration using a rat sciatic nerve (SN) injury model.
To develop a methodology for identifying differentially expressed ncRNAs and their protein targets from existing microarray data.
To analyze the transcriptome-level effects of ncRNAs on neuropathic pain.

Main Methods:

Developed a novel methodology to identify differentially expressed ncRNAs and protein-coding genes from microarray data.
Utilized contextual analysis to identify potential protein-coding targets for ncRNAs based on genomic proximity.
Constructed gene networks from putative targets to infer interactomic relationships and assess relevance to NP.

Main Results:

Identified significant differential expression of long intergenic ncRNAs (lincRNAs), antisense RNAs (asRNAs), and pseudogenes in both SN and dorsal root ganglion (DRG) tissues.
Contextual analysis of pseudogenes revealed targets associated with neurodegeneration and neurogenesis.
Network analysis identified connections to known disease-related proteins and pathways, including olfactory receptors.

Conclusions:

ncRNAs, particularly pseudogenes, play a significant role in nerve injury and regeneration.
Repurposing gene expression data through meta-analysis is a valuable approach for understanding complex biological processes like neuropathic pain.
Findings provide a foundation for further research into ncRNA-based diagnostics and therapeutics for neurological disorders.