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Roles of FGF Signals in Heart Development, Health, and Disease

Nobuyuki Itoh1, Hiroya Ohta2, Yoshiaki Nakayama2

  • 1Medical Innovation Center, Kyoto University Graduate School of Medicine Kyoto, Japan.

Frontiers in Cell and Developmental Biology
|November 3, 2016
PubMed

Insights

Fibroblast Growth Factors (FGFs) are crucial for heart development and function. This study explores FGF signaling

Area of Science:

  • Cardiovascular Biology
  • Developmental Biology
  • Molecular Signaling

Background:

  • The heart, vital for nutrient and oxygen transport, is the first organ to develop.
  • Fibroblast Growth Factors (FGFs) are signaling proteins with diverse roles in development, health, and disease.
  • The FGF family has 22 members, with several implicated in cardiac development and pathophysiology.

Approach:

  • Review of findings from mouse models and human FGF signaling disorders.
  • Analysis of paracrine and endocrine FGF roles in embryonic and postnatal heart development.
  • Examination of FGF involvement in cardiac pathophysiology and stem cell differentiation.

Key Points:

  • Paracrine FGFs (FGF8, FGF9, FGF10, FGF16) are critical during embryonic heart development.
  • Postnatal heart pathophysiology involves paracrine FGFs (FGF2, FGF9, FGF10, FGF16).
  • Endocrine FGFs (FGF15/19, FGF21, FGF23) also exhibit paracrine roles in cardiac contexts, with altered serum levels in heart disease.
  • FGF2 and FGF10 promote cardiac differentiation and reprogramming of fibroblasts.

Conclusions:

  • FGF signaling plays multifaceted roles in heart development, health, and disease.
  • Understanding FGF roles offers potential therapeutic strategies for cardiac disorders.

Keywords:
FGFbiomarkerdevelopmentdifferentiationdiseaseheart

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