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Estimated cognitive decline in patients with schizophrenia: A multicenter study
Haruo Fujino1,2, Chika Sumiyoshi3, Yuka Yasuda4
1Graduate School of Human Sciences, Osaka University, Osaka, Japan.
Patients with schizophrenia experience significant cognitive decline, with an average estimated intellectual functioning drop of 16.3 points. This cognitive decline impacts a substantial portion of individuals diagnosed with schizophrenia.
Area of Science:
- Neuroscience
- Psychiatry
- Cognitive Psychology
Background:
- Cognitive decline is a recognized symptom in schizophrenia, though its extent varies among patients.
- Understanding the degree of cognitive decline is crucial for managing schizophrenia.
Purpose of the Study:
- To quantify the estimated cognitive decline in schizophrenia patients.
- To compare estimated premorbid intellectual functioning with current intellectual functioning in schizophrenia.
Main Methods:
- Utilized the Wechsler Adult Intelligence Scale-III (WAIS-III) for current IQ assessment.
- Employed the Japanese Adult Reading Test-25 to estimate premorbid IQ.
- Calculated cognitive decline as the difference between estimated premorbid IQ and current Full-Scale IQ (FSIQ).
Main Results:
- Schizophrenia patients exhibited significantly greater estimated cognitive decline compared to healthy controls.
- The mean difference score (cognitive decline) was -16.3 in schizophrenia patients.
- 39.7% of patients showed a decline of 20 points or more in estimated cognitive function.
Conclusions:
- The study provides a distribution of cognitive decline scores in schizophrenia.
- Findings can aid in assessing the severity of cognitive decline and identifying affected individuals.
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