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Diabetes insipidus complicating myelofibrosis
T L Dornan1, G Gillett, P A Jones
1City Hospital, Nottingham, UK.
Postgraduate Medical Journal
|January 1, 1989
Summary
A 68-year-old man experienced cranial diabetes insipidus due to myelofibrosis. This rare complication, potentially caused by infiltration or infarction, affected the hypothalamus.
Area of Science:
- Hematology
- Endocrinology
- Neurology
Background:
- Myelofibrosis is a bone marrow disorder.
- Cranial diabetes insipidus results from impaired antidiuretic hormone function.
Observation:
- A 68-year-old male patient with myelofibrosis developed cranial diabetes insipidus.
- This occurred 3 years after myelofibrosis diagnosis, coinciding with increased nucleated cell count.
Findings:
- No mass lesion was identified via CT or MRI.
- Hypothalamic damage is suggested as the cause of diabetes insipidus.
Implications:
- This case suggests a previously unreported complication of myelofibrosis.
- Hypothalamic infiltration or infarction may occur in myelofibrosis.