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Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
Published on: February 9, 2024
Thyroid Ultrasound and Other Imaging Procedures in the Pediatric Age
Federica Guidoccio1, Mariano Grosso, Federica Orsini
1Regional Center of Nuclear Medicine, University of Pisa, Pisa, Italy..
Insights
This review reappraises diagnostic imaging for pediatric thyroid carcinoma, highlighting ultrasound as a first-line tool. Advanced techniques like PET/CT are crucial for staging and treatment response in pediatric thyroid cancer.
Area of Science:
- Pediatric Radiology
- Nuclear Medicine
- Oncology Imaging
Background:
- Thyroid carcinoma is a significant concern in pediatric patients.
- Accurate diagnosis and staging are critical for effective treatment planning.
- Diagnostic imaging plays a pivotal role in evaluating suspected thyroid nodules and malignancy.
Purpose of the Study:
- To reappraise current diagnostic imaging procedures for pediatric thyroid carcinoma.
- To evaluate the roles of various imaging modalities in diagnosis, staging, and treatment response assessment.
- To provide an updated overview for clinicians managing pediatric thyroid cancer.
Main Methods:
- Review of diagnostic imaging techniques including thyroid ultrasound (US), ultrasound-guided fine-needle aspiration biopsy (FNAB), scintigraphy, CT, MRI, and PET/CT.
- Analysis of the utility of each modality in the pediatric population.
- Synthesis of current literature on imaging in pediatric thyroid cancer.
Main Results:
- Thyroid US is the primary imaging modality, offering anatomical and perfusion details.
- Scintigraphy provides functional information, complementing anatomical data.
- CT and MRI serve supplemental roles, while PET/CT and novel nuclear agents are vital for staging and treatment evaluation.
Conclusions:
- A multimodal imaging approach is essential for comprehensive evaluation of pediatric thyroid carcinoma.
- Ultrasound remains the cornerstone for initial assessment of thyroid nodules.
- Nuclear medicine, including PET/CT, is increasingly important for advanced disease management and response monitoring.
Abstract:
The purpose of this review is to provide a reappraisal of the diagnostic imaging procedures for thyroid carcinoma in pediatric patients, including thyroid ultrasound (US), ultrasound-guided fine-needle aspiration biopsy (FNAB), scintigraphy, radiological techniques (CT, MR), and PET/CT. The most frequent indication for thyroid imaging is characterization of a palpable mass in the neck or thyroid gland. Thyroid US is a first-line examination for visualizing the thyroid gland as it provides anatomic and perfusion information; on the other hand, scintigraphy mostly provides functional information but combined with some anatomic information as well. CT and MRI have a supplemental role in these patients. Furthermore, with the introduction of PET/CT and the development of new imaging agents, nuclear medicine plays an important role in different phases of neoplastic disease in terms of both staging and evaluation of response to medical/surgical treatments.
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