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Related Concept Videos

Pulmonary Tuberculosis II01:28

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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
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Necrosis01:16

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Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Pulmonary Tuberculosis III01:31

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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
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Related Experiment Video

Updated: Mar 12, 2026

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
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Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

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[Necrotizing sarcoid granulomatosis].

L A Semenova1, S G Radenska-Lopovok2, S A Burtseva3

  • 1V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia; Central Research Institute of Tuberculosis, Moscow, Russia.

Arkhiv Patologii
|November 3, 2016
PubMed
Summary

Necrotizing sarcoid granulomatosis (NSG) is a rare small-vessel vasculitis affecting only the lungs. Diagnosis relies on morphological examination due to nonspecific symptoms and poorly understood origins.

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Area of Science:

  • Pulmonary Medicine
  • Pathology
  • Immunology

Background:

  • Necrotizing sarcoid granulomatosis (NSG) is characterized by productive small-vessel vasculitis and sarcoid-like granulomas with ischemic necrosis.
  • This rare condition exclusively involves the lung, presenting nonspecific clinical symptoms that often delay diagnosis.

Discussion:

  • Morphological examination is the primary diagnostic method for NSG.
  • Pathogenesis involves immune complex inflammation in vessel walls, forming macrophage-histiocytic granulomas lacking epithelioid cells.
  • Etiology and pathogenesis of NSG remain largely unelucidated.

Key Insights:

  • NSG is a distinct entity within vasculitis, primarily diagnosed via histology.
  • The lung is the sole organ affected, complicating early clinical detection.
  • Distinguishing NSG from tuberculosis, sarcoidosis, and granulomatosis with polyangiitis is crucial.

Outlook:

  • Further research into the etiology and pathogenesis of NSG is warranted.
  • Improved diagnostic criteria may enhance early detection rates.
  • Understanding NSG's unique inflammatory pathways could inform targeted therapies.