Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Depression: Overview

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...

Depressive Disorders: Etiology

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...

Depressive Disorders: MDD and Dysthymia

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...

Adrenal Gland Disorders

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...

Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.

Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Functional and Radiological Outcomes of Calcar Buttress Biplane Double-Supported Screw Fixation (BDSF) Using a Locking Compression Screw System for Intracapsular Femoral Neck Fractures: A Prospective Observational Study.

Cureus·2026

Same author

Safe resumption of Electroconvulsive therapy shortly after permanent pacemaker implantation in an elderly patient with psychotic depression: A case report and focused review of peri-procedural considerations.

Asian journal of psychiatry·2026

Same author

Mechanistic Insights into metformin's neuroprotective effects against drug-induced neurotoxicity.

Metabolic brain disease·2026

Same author

EUS-Guided FNA: Cracking the Diagnostic Dilemma of Unexplained Low Serum-Ascites Albumin Gradient (SAAG) Ascites.

Digestive diseases and sciences·2026

Same author

Multidisciplinary Management of Paediatric Nasolacrimal Duct Obstruction at a Tertiary Hospital: A Five-Year Review.

Cureus·2026

Same author

Discordant Cortisol Responses to Spontaneous Hypoglycaemia Versus Adrenocorticotropic Hormone Stimulation: A Diagnostic Challenge for Hypothalamic-Pituitary-Adrenal Axis Assessment.

Indian journal of endocrinology and metabolism·2026

Search research articles

Related Experiment Video

Updated: Mar 12, 2026

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

Cushing's Disease presenting as Suicidal Depression.

Jatinder Mokta¹, Ravi Sharma², Kiran Mokta³

¹Professor, Department of Medicine.

The Journal of the Association of Physicians of India

|November 3, 2016

Summary

Cushing disease can cause severe depression. Early diagnosis and treatment of Cushing disease fully resolved suicidal depression in a reported case.

More Related Videos

Author Spotlight: Establishing a Rodent Model for Investigating Depression Factors in Traditional Mongolian Medicine

Author Spotlight: Establishing a Rodent Model for Investigating Depression Factors in Traditional Mongolian Medicine

Published on: October 27, 2023

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice

Published on: May 15, 2019

Related Experiment Videos

Last Updated: Mar 12, 2026

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

Author Spotlight: Establishing a Rodent Model for Investigating Depression Factors in Traditional Mongolian Medicine

Author Spotlight: Establishing a Rodent Model for Investigating Depression Factors in Traditional Mongolian Medicine

Published on: October 27, 2023

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice

A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice

Published on: May 15, 2019

Area of Science:

Endocrinology
Neuroscience
Psychiatry

Background:

Cushing disease is a rare endocrine disorder caused by excess cortisol production.
Hypercortisolism can manifest with various psychiatric symptoms, including depression.

Observation:

A patient presented with suicidal depression as the primary symptom.
The patient was diagnosed with Cushing disease.

Findings:

Prompt diagnosis and management of Cushing disease were initiated.
Treatment successfully resolved the symptoms of hypercortisolism.
The patient's suicidal depression fully remitted following treatment.

Implications:

This case highlights the critical link between endocrine disorders and mental health.
Early identification and treatment of Cushing disease can lead to complete psychiatric recovery.
Clinicians should consider endocrine causes in patients with severe, unexplained depression.