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Nervous Tissue: Myelin01:25

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Related Experiment Video

Updated: Mar 12, 2026

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin
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Combined Central and Peripheral Demyelination.

Pranav B Joshi1, Sudhir V Shah2, Mayank A Patel3

  • 1Asst. Prof.

The Journal of the Association of Physicians of India
|November 3, 2016
PubMed
Summary
This summary is machine-generated.

This study presents a rare case of simultaneous central and peripheral nervous system demyelination. A patient with Chronic Inflammatory Demyelinating Polyneuropathy developed Acute Transverse Myelitis, suggesting a common cause.

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Area of Science:

  • Neurology
  • Neuroimmunology
  • Demyelinating Diseases

Background:

  • Demyelinating disorders typically affect either the central nervous system (CNS) or peripheral nervous system (PNS) in isolation.
  • Combined CNS and PNS demyelination is infrequent but documented.
  • Understanding shared etiological factors is crucial for diagnosis and treatment.

Observation:

  • A middle-aged male patient diagnosed with Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) showed positive response to immunomodulatory treatment.
  • Following treatment for CIDP, the patient subsequently developed Acute Transverse Myelitis (ATM).

Findings:

  • The case highlights a rare instance of concurrent demyelination affecting both the CNS (ATM) and PNS (CIDP) in a single patient.
  • Recent research identifies the NF186 protein as a potential common substrate involved in this rare clinical presentation.

Implications:

  • This case underscores the possibility of a shared underlying mechanism in seemingly distinct demyelinating disorders.
  • Further investigation into proteins like NF186 may reveal novel therapeutic targets for combined CNS and PNS demyelination.
  • Recognizing this rare entity can improve diagnostic accuracy and patient management.