Related Experiment Video
Updated: Mar 12, 2026

Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
Decreased rates of hypoglycemia following implementation of a comprehensive computerized insulin order set and
Naina Sinha Gregory1, Jane Jeffrie Seley1, Linda M Gerber1
1a Joan and Sanford I Weill Medical College of Cornell University , Endocrinology , New York , NY , USA.
Insights
Implementing a computerized insulin order set and titration algorithm reduced hypoglycemia in hospitalized patients. While effective in lowering low blood sugar, this intervention also led to increased hyperglycemia rates.
Area of Science:
- Inpatient glycemic control
- Medical informatics
- Clinical quality improvement
Background:
- Hospital hyperglycemia affects over one-third of patients.
- Improved glycemic control is linked to better patient outcomes.
- Achieving target glycemic levels in hospitals remains a significant challenge.
Purpose of the Study:
- To assess the impact of a computerized insulin order set and titration algorithm.
- To evaluate effects on inpatient hypoglycemia and overall glycemic control.
Main Methods:
- A prospective observational study in an academic medical center.
- Involved hospital-wide implementation of an insulin order set.
- Added an insulin titration algorithm in pilot units, analyzing blood glucose data.
Main Results:
- The insulin order set decreased hypoglycemia (1.92% to 1.61%) but increased hyperglycemia (24.02% to 27.27%).
- The addition of the titration algorithm further reduced hypoglycemia (2.57% to 1.82%) and increased hyperglycemia (31.76% to 41.33%).
Conclusions:
- A computerized insulin order set and algorithm effectively reduced hypoglycemia.
- The reduction in hypoglycemia was accompanied by an increase in hyperglycemia.
- Integrating the algorithm into the electronic medical record could improve adoption and adherence.
Objectives:
More than one-third of hospitalized patients have hyperglycemia. Despite evidence that improving glycemic control leads to better outcomes, achieving recognized targets remains a challenge. The objective of this study was to evaluate the implementation of a computerized insulin order set and titration algorithm on rates of hypoglycemia and overall inpatient glycemic control.
Methods:
A prospective observational study evaluating the impact of a glycemic order set and titration algorithm in an academic medical center in non-critical care medical and surgical inpatients. The initial intervention was hospital-wide implementation of a comprehensive insulin order set. The secondary intervention was initiation of an insulin titration algorithm in two pilot medicine inpatient units. Point of care testing blood glucose reports were analyzed. These reports included rates of hypoglycemia (BG < 70 mg/dL) and hyperglycemia (BG >200 mg/dL in phase 1, BG > 180 mg/dL in phase 2).
Results:
In the first phase of the study, implementation of the insulin order set was associated with decreased rates of hypoglycemia (1.92% vs 1.61%; p < 0.001) and increased rates of hyperglycemia (24.02% vs 27.27%; p < 0.001) from 2010 to 2011. In the second phase, addition of a titration algorithm was associated with decreased rates of hypoglycemia (2.57% vs 1.82%; p = 0.039) and increased rates of hyperglycemia (31.76% vs 41.33%; p < 0.001) from 2012 to 2013.
Conclusions:
A comprehensive computerized insulin order set and titration algorithm significantly decreased rates of hypoglycemia. This significant reduction in hypoglycemia was associated with increased rates of hyperglycemia. Hardwiring the algorithm into the electronic medical record may foster adoption.
More Related Videos
08:32Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
Published on: January 4, 2018
07:35Author Spotlight: Investigating the Blood Glucose Homeostasis in Murine Brain Using a Cost-Effective Hyperglycemic And Hypoglycemic Clamp Technique
Published on: January 26, 2024
Related Concept Videos
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Hypoglycemia and Glucagon
Insulin Formulations: Types and Delivery
Short-acting insulins are divided into...
SBAR II: Application of SBAR
SBAR Report from a Nurse to a Health Care Provider
S: "Hello, Dr. Smith. This is Jane, RN, from the Med Surg unit. I am calling to tell you about Ms. White in Room 210, who is experiencing increased pain and redness at her incision site. Her recent...
Oral Hypoglycemic Agents: Glinides
Dipeptidyl Peptidase 4 Inhibitors