Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

1.2K
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
1.2K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.8K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.8K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

2.2K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
2.2K
Tumor Immunotherapy01:27

Tumor Immunotherapy

2.1K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.1K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

85.7K
Overview
85.7K
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

640
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
640

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Psychological Burden of Chronic Kidney Disease Caregivers.

Iranian journal of kidney diseases·2026
Same author

Therapeutic Apheresis in Pediatric Renal Transplant Recipients.

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation·2024
Same author

Second and Third Kidney Transplants.

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation·2024
Same author

The Effects of Remdesivir and Dexamethasone on Renal Sirtuin-1 Expression and Renal Function in Male Rats.

Applied biochemistry and biotechnology·2023
Same author

Effect of Lower- versus Higher-Intensity Isometric Handgrip Training in Adults with Hypertension: A Randomized Controlled Trial.

Journal of cardiovascular development and disease·2022
Same author

Expanded Criteria Donors.

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation·2022

Related Experiment Video

Updated: Mar 12, 2026

A Novel Microsurgical Model for Heterotopic, En Bloc Chest Wall, Thymus, and Heart Transplantation in Mice
12:24

A Novel Microsurgical Model for Heterotopic, En Bloc Chest Wall, Thymus, and Heart Transplantation in Mice

Published on: January 23, 2016

9.8K

Cell Therapy in Solid-Organ Transplant.

Hassan Argani1

  • 1From Urology and Nephrology Research Center of Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation
|November 3, 2016
PubMed
Summary

Cell therapy offers a promising alternative to traditional immunosuppression in solid-organ transplant. This approach uses immunoregulatory cells to reduce adverse effects and potentially induce long-term tolerance.

Area of Science:

  • Transplant immunology
  • Regenerative medicine
  • Bioengineering medicine

Background:

  • Cell therapy is explored for immunomodulation and graft function in solid-organ transplant.
  • Current understanding requires clarification on indications, mechanisms, cell types, and safety profiles.

Purpose of the Study:

  • To review the current status of cell therapy in solid-organ transplantation.
  • To address key questions regarding its necessity, efficacy, and safety.

Main Methods:

  • Review of existing literature on cell therapy in solid-organ transplant.
  • Analysis of potential cell types and their mechanisms of action.
  • Evaluation of safety data and comparison with conventional immunosuppression.

More Related Videos

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells
05:32

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

Published on: February 16, 2024

1.0K
Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus
11:18

Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus

Published on: May 7, 2012

13.4K

Related Experiment Videos

Last Updated: Mar 12, 2026

A Novel Microsurgical Model for Heterotopic, En Bloc Chest Wall, Thymus, and Heart Transplantation in Mice
12:24

A Novel Microsurgical Model for Heterotopic, En Bloc Chest Wall, Thymus, and Heart Transplantation in Mice

Published on: January 23, 2016

9.8K
In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells
05:32

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

Published on: February 16, 2024

1.0K
Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus
11:18

Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus

Published on: May 7, 2012

13.4K

Main Results:

  • Cell therapy risks are comparable to blood transfusions, with potential to decrease immunosuppressive drug side effects.
  • Immunoregulatory cells offer active, targeted functions, unlike passive drug inhibition.
  • Indications include treating ischemic-reperfusion injury, preventing chronic allograft nephropathy, and inducing tolerance.

Conclusions:

  • Various cell types (e.g., mesenchymal stromal cells, regulatory T cells) show promise.
  • Further research is needed to clarify the efficacy and safety of each cell type for widespread clinical adoption.
  • Cell therapy has the potential to significantly transform solid-organ transplant science.