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Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
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Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
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Oral Drug Delivery Systems: Continuous-Release Systems

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Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
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Magnetically Controlled Drug Release System through Magnetomechanical Actuation.

João Barbosa1, Daniela Maria Correia1,2, Renato Gonçalves1,2

  • 1Centro/Departamento de Física, Universidade do Minho, 4710-057, Braga, Portugal.

Advanced Healthcare Materials
|November 3, 2016
PubMed
Summary

This study presents a novel magnetic-field-controlled drug release system using poly(l-lactic acid) membranes with zeolite and Terfenol-D. The system significantly enhances drug release rates when exposed to an alternating magnetic field.

Keywords:
biomedical materialsdrug releasesmagnetostrictive materialsmembraneszeolites

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Materials Engineering

Background:

  • Developing controlled drug release systems is crucial for therapeutic efficacy.
  • Magnetic field-responsive materials offer novel mechanisms for modulating drug release kinetics.
  • Poly(l-lactic acid) (PLLA) membranes are biocompatible and suitable for drug delivery applications.

Purpose of the Study:

  • To develop and characterize a PLLA microporous membrane system for magnetic-field-modulated drug release.
  • To investigate the release kinetics of ibuprofen (IBU) from the developed system under varying magnetic field conditions.
  • To evaluate the influence of Terfenol-D (TD) content and magnetic field intensity on drug release.

Main Methods:

  • Fabrication of PLLA microporous membranes incorporating zeolite (Faujasite) and magnetostrictive Terfenol-D (TD).
  • Characterization of membrane properties and drug loading.
  • In vitro release studies of ibuprofen (IBU) with and without applied AC magnetic fields.
  • Analysis of release kinetics using the Korsmeyer-Peppas model.

Main Results:

  • Without a magnetic field, IBU release followed first-order kinetics.
  • Application of an AC magnetic field increased IBU release rate by over 30%, exhibiting super case-II behavior.
  • Increased TD content (10% to 20%) decreased IBU release, while higher magnetic field intensity (100 to 200 mT) increased IBU release.

Conclusions:

  • The developed PLLA/zeolite/TD membrane system effectively modulates drug release using an external magnetic field.
  • Magnetic field-induced swelling or erosion mechanisms, driven by TD particles, are responsible for enhanced release.
  • This technology holds promise for advanced, externally controlled drug delivery applications.