Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Real-world Safety Profile of Avacincaptad Pegol in the Management of Geographic Atrophy.

Ophthalmic surgery, lasers & imaging retina·2026

Same author

American Society of Retina Specialists Clinical Practice Guidelines on Multimodal Imaging for Retinal Disease.

Journal of vitreoretinal diseases·2024

Same author

Faricimab in Previously Treated Eyes With Neovascular Age-Related Macular Degeneration: An Assessment of Durability and Treatment Outcomes.

Ophthalmic surgery, lasers & imaging retina·2024

Same author

Vision Loss Reduction with Avacincaptad Pegol for Geographic Atrophy: A 12-Month Post Hoc Analysis of the GATHER1 and GATHER2 Trials.

Ophthalmology. Retina·2024

Same author

INTRAOCULAR INFLAMMATION INCIDENCE AFTER INTRAVITREAL BROLUCIZUMAB INJECTION FOR EXUDATIVE AGE-RELATED MACULAR DEGENERATION.

Retina (Philadelphia, Pa.)·2023

Same author

Ocular Toxoplasmosis after Exposure to Wild Game.

Ocular immunology and inflammation·2021

Same journal

Acute Paracentral Scotoma Following Cosmetic Penile Filler Injection.

Retinal cases & brief reports·2026

Same journal

Intravitreous Methotrexate and Rituximab for Bilateral Diffuse Uveal Melanocytic Proliferation (BDUMP).

Retinal cases & brief reports·2026

Same journal

Multimodal imaging of ASHH in a case of Scrub Typhus Retinopathy.

Retinal cases & brief reports·2026

Same journal

Pathogenic Variants in HGSNAT associated with Autosomal Recessive Retinitis Pigmentosa without Overt Sanfilippo Syndrome.

Retinal cases & brief reports·2026

Same journal

Macular Choroidal Neovascularization in Peripapillary Hyperreflective Ovoid Mass-Like Structures (PHOMS): case report.

Retinal cases & brief reports·2026

Same journal

Endogenous Streptococcus Anginosus Endophthalmitis: A Case Report and Review of the Literature.

Retinal cases & brief reports·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 12, 2026

Author Spotlight: An Innovative Approach to Neural Electrical Stimulation Using Calcium Imaging

Author Spotlight: An Innovative Approach to Neural Electrical Stimulation Using Calcium Imaging

Published on: August 18, 2023

GEMCITABINE-INDUCED RETINOPATHY.

Jaclyn L Kovach¹

¹Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.

Retinal Cases & Brief Reports

|November 3, 2016

Summary

This summary is machine-generated.

This case study identifies gemcitabine as a cause of Purtscher-like retinopathy, a form of ischemic retinopathy. Vision improved after discontinuing the chemotherapy drug, highlighting its potential ocular toxicity.

More Related Videos

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Published on: May 23, 2025

Author Spotlight: Photodynamic Therapy as a Novel Approach to Induce Petite Colonies in Drug-Resistant Candida for Antifungal Research

Author Spotlight: Photodynamic Therapy as a Novel Approach to Induce Petite Colonies in Drug-Resistant Candida for Antifungal Research

Published on: March 29, 2024

Related Experiment Videos

Last Updated: Mar 12, 2026

Author Spotlight: An Innovative Approach to Neural Electrical Stimulation Using Calcium Imaging

Author Spotlight: An Innovative Approach to Neural Electrical Stimulation Using Calcium Imaging

Published on: August 18, 2023

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Published on: May 23, 2025

Author Spotlight: Photodynamic Therapy as a Novel Approach to Induce Petite Colonies in Drug-Resistant Candida for Antifungal Research

Author Spotlight: Photodynamic Therapy as a Novel Approach to Induce Petite Colonies in Drug-Resistant Candida for Antifungal Research

Published on: March 29, 2024

Area of Science:

Ophthalmology
Oncology
Medical Toxicology

Background:

Gemcitabine is a widely used chemotherapy agent for various cancers.
Ocular side effects of gemcitabine are rare but can be severe.
Purtscher-like retinopathy is a rare condition characterized by visual disturbances and retinal changes.

Observation:

A 68-year-old woman with a history of leiomyosarcoma, diabetes, and hypertension presented with bilateral vision loss.
The patient had completed five cycles of gemcitabine and docetaxel chemotherapy.
Clinical examination revealed Purtscher-like retinopathy.

Findings:

The Purtscher-like retinopathy resolved after cessation of gemcitabine.
No cystoid macular edema or retinal neovascularization developed.
This suggests a direct link between gemcitabine and the observed retinopathy.

Implications:

Gemcitabine can induce ischemic retinopathy, mimicking Purtscher's retinopathy.
Ophthalmologists and oncologists should be aware of this potential adverse effect.
Early recognition and discontinuation of gemcitabine may prevent permanent vision loss and systemic complications like myocardial or renal ischemia.