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Intralymphatic nevus cells in benign nevi.

Cem Leblebici1, Canan Kelten1, Mehmet Salih Gurel2

  • 1Department of Pathology, Istanbul Education and Research Hospital, Istanbul, Turkey.

Annals of Diagnostic Pathology
|November 4, 2016
PubMed
Summary

Benign nevus cells can travel into lymphatic vessels, forming aggregates in lymph nodes. This study supports the mechanical transport theory for nevus cell migration in benign nevi.

Keywords:
IntralymphaticMechanical transport theoryMelanocytic nevusNevus cell aggregates in lymph nodesNevus cells

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Area of Science:

  • Dermatopathology
  • Surgical Pathology
  • Oncology Research

Background:

  • The origin of nevus cell aggregates in lymph nodes is debated.
  • The mechanical transport theory proposes cell migration from cutaneous nevi to lymph nodes.

Purpose of the Study:

  • To investigate the mechanical transport theory of nevus cell aggregates in benign nevi.
  • To identify evidence supporting the migration of nevus cells into lymphatic vessels.

Main Methods:

  • Prospective evaluation of 369 benign cutaneous nevi.
  • Immunohistochemical staining for CD31 and podoplanin (D2-40) in cases with intralymphatic nevus cell aggregates (ILNA) or protrusions.
  • Histological and immunohistochemical verification of ILNAs.

Main Results:

  • 13 intralymphatic nevus cell aggregates (ILNAs) were identified in 10 patients.
  • Nevus cell protrusions into lymphatics were observed in all ILNA cases and 27 other nevi.
  • Nevus cells showed perilymphatic orientation and affinity for lymphatics.

Conclusions:

  • Findings support the mechanical transport theory for ILNA formation.
  • Nevus cells may migrate into lymphatic spaces due to mechanical effects and endothelial affinity.
  • Local trauma could dislodge ILNAs, facilitating transport to lymph nodes.