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Aggressive B-cell lymphomas: frequency, immunophenotype, and genetics in a reference laboratory population.

Yalda B Naeini1, Annie Wu1, Dennis P O'Malley2

  • 1Department of Pathology and Laboratory Medicine, UCLA, 10833 Le Conte Ave, Los Angeles, CA.

Annals of Diagnostic Pathology
|November 4, 2016
PubMed
Summary

This study analyzed 760 aggressive B-cell lymphomas, confirming the World Health Organization classification for diffuse large B-cell lymphoma (DLBCL) and its subtypes. Findings support current diagnostic approaches for these lymphomas.

Keywords:
Burkitt lymphomaCell of originDiffuse large B-cell lymphomaDouble-hit lymphomaFISHImmunohistochemistryMYC

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Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Diffuse large B-cell lymphoma (DLBCL) is the most prevalent lymphoma globally.
  • Accurate classification of DLBCL and related aggressive B-cell lymphomas is crucial for diagnosis and treatment.
  • Subtypes and overlapping features necessitate detailed immunophenotypic and genetic analysis.

Purpose of the Study:

  • To evaluate a large cohort of DLBCL and other aggressive B-cell lymphomas.
  • To assess the frequency and characteristics of different subtypes.
  • To validate the World Health Organization classification and explore specific diagnostic markers.

Main Methods:

  • Analysis of 760 cases using a uniform immunohistochemical panel and genetic methods.
  • Evaluation of DLBCL subtypes, including CD5+ DLBCL, T-cell/histiocyte-rich large B-cell lymphomas, and Epstein-Barr virus-positive DLBCL.
  • Inclusion of Burkitt lymphoma and double-hit lymphoma cases for comparison.

Main Results:

  • DLBCL comprised 89% of the study group, with specific frequencies noted for CD5+ DLBCL, T-cell/histiocyte-rich large B-cell lymphomas, and EBV-positive DLBCL.
  • The study included 39 cases each of Burkitt lymphoma and double-hit lymphoma.
  • Distinct immunophenotypic and genetic findings were documented for the evaluated cases.

Conclusions:

  • The study results generally support the current World Health Organization classification of DLBCL.
  • Findings reinforce the utility of combined immunohistochemical and genetic approaches in diagnosing aggressive B-cell lymphomas.
  • Further investigation into cell-of-origin classification, MYC alterations, and EBV association is highlighted.