Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anchoring Junctions01:03

Anchoring Junctions

5.4K
Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
5.4K
Mechanism of Lamellipodia Formation01:31

Mechanism of Lamellipodia Formation

3.9K
Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
3.9K
Desmosomes01:05

Desmosomes

8.7K
The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein...
8.7K
Tension Response at Adherens Junctions01:26

Tension Response at Adherens Junctions

4.0K
The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin...
4.0K
Adherens Junctions01:24

Adherens Junctions

7.3K
Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
7.3K
Cell Motility through Blebbing01:16

Cell Motility through Blebbing

2.6K
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Daily sitting time and past-year falls in Japanese adults: an exploratory cross-sectional analysis.

Frontiers in sports and active living·2026
Same author

The "en bloc" shift: ipsilateral and contralateral abducens nerve palsy following microvascular decompression for trigeminal neuralgia caused by vertebrobasilar dolichoectasia. Illustrative cases.

Journal of neurosurgery. Case lessons·2026
Same author

Bleb expansion requires transient membrane invaginations that sequester curvature-preferring proteins.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Corrigendum to "Influential factors of long-term and seasonal <sup>137</sup>Cs change in agricultural and forested rivers: Temperature, water quality and an intense Typhoon Event" [Environ. Pollut. 338, 122617].

Environmental pollution (Barking, Essex : 1987)·2026
Same author

Corrigendum to "Response of <sup>137</sup>Cs dynamics in dam lakes to temperature and weather conditions" [Environ. Pollut. 378, 126445].

Environmental pollution (Barking, Essex : 1987)·2026
Same author

Bleb-based extravasation uses conserved morphodynamics but divergent calcium control.

Nature communications·2026

Related Experiment Video

Updated: Mar 12, 2026

Reconstitution of Actin-Based Motility with Commercially Available Proteins
08:40

Reconstitution of Actin-Based Motility with Commercially Available Proteins

Published on: October 28, 2022

2.4K

DAAM1 stabilizes epithelial junctions by restraining WAVE complex-dependent lateral membrane motility.

Tamako Nishimura1, Shoko Ito2, Hiroko Saito2

  • 1RIKEN Center for Developmental Biology, Chuo-ku, Kobe 650-0047, Japan tnishimura@cdb.riken.jp takeichi@cdb.riken.jp.

The Journal of Cell Biology
|November 4, 2016
PubMed
Summary

DAAM1 actin regulation normally restrains lateral membrane contact (LC) motility. Loss of DAAM1 enhances LC motility and epithelial cell invasion, revealing a key mechanism in epithelial architecture and cell behavior.

Failed At:

2026-07-14T07:25:30.472925+00:00

More Related Videos

Measuring Cell-Edge Protrusion Dynamics during Spreading using Live-Cell Microscopy
05:50

Measuring Cell-Edge Protrusion Dynamics during Spreading using Live-Cell Microscopy

Published on: November 1, 2021

2.9K
Analysis of the Epithelial Damage Produced by Entamoeba histolytica Infection
11:49

Analysis of the Epithelial Damage Produced by Entamoeba histolytica Infection

Published on: June 12, 2014

19.3K

Related Experiment Videos

Last Updated: Mar 12, 2026

Reconstitution of Actin-Based Motility with Commercially Available Proteins
08:40

Reconstitution of Actin-Based Motility with Commercially Available Proteins

Published on: October 28, 2022

2.4K
Measuring Cell-Edge Protrusion Dynamics during Spreading using Live-Cell Microscopy
05:50

Measuring Cell-Edge Protrusion Dynamics during Spreading using Live-Cell Microscopy

Published on: November 1, 2021

2.9K
Analysis of the Epithelial Damage Produced by Entamoeba histolytica Infection
11:49

Analysis of the Epithelial Damage Produced by Entamoeba histolytica Infection

Published on: June 12, 2014

19.3K