Biochemical and hormonal parameters in patients with multiple trauma

Area of Science:

• Biochemistry
• Endocrinology
• Trauma Medicine

Background:

• Multiple trauma patients exhibit complex metabolic and endocrine dysregulation.
• Assessing these changes is crucial for predicting patient outcomes.
• Biomarker monitoring aids in understanding trauma-induced physiological responses.

Purpose of the Study:

• To evaluate metabolic-endocrine alterations in multiple trauma patients.
• To correlate biomarker levels with patient survival.
• To identify key indicators of prognosis following severe injury.

Main Methods:

• Quantified injury severity using the Injury Severity Score.
• Measured serum levels of lactate, creatinine, bilirubin, somatomedin, and thyroid hormones in 51 patients for six days post-injury.
• Assessed neopterin levels in 26 patients.
• Compared biomarker profiles between survivor and non-survivor groups.

Main Results:

• Significant differences (p<0.05 to p<0.01) were observed in Global Index Scores and Septic Severity Scores between survivors and non-survivors.
• Lactate, somatomedin, neopterin, and thyroid hormone levels showed statistically significant variations between the groups.
• These biomarkers demonstrated prognostic relevance in the context of multiple trauma.

Conclusions:

• Metabolic and endocrine parameters, including lactate, somatomedin, neopterin, and thyroid hormones, are significantly altered in multiple trauma patients.
• These alterations correlate with patient outcomes, distinguishing survivors from non-survivors.
• Biomarker monitoring offers valuable insights into the physiological response to trauma and aids in outcome prediction.