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Updated: Mar 12, 2026
Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy
Published on: May 16, 2022
Multimodality imaging in nanomedicine and nanotheranostics
Xue Li1, Xue-Ning Zhang2, Xiao-Dong Li2
1School of Life Sciences, Tianjin University, Tianjin Engineering Center of Micro-Nano Biomaterials and Detection-Treatment Technology, and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300072, China; Department of Radiology and Department of Radiation Oncology, Second Affiliated Hospital of Tianjin Medical University, Tianjin 300211, China.
Multimodal imaging using nanoparticles offers comprehensive tumor diagnostic data. This nanomedicine approach integrates multiple imaging techniques for enhanced accuracy and theranosis.
Area of Science:
- Nanomedicine
- Medical Imaging
- Oncology
Background:
- Accurate tumor diagnosis requires detailed information often unavailable from single imaging modalities.
- Current imaging techniques have limitations in providing comprehensive data for diagnosis.
Purpose of the Study:
- To review recent advancements in multifunctional nanoparticles for multimodal imaging.
- To explore the biomedical applications of these nanoparticles in cancer diagnosis and theranosis.
Main Methods:
- Review of studies focusing on intrinsic nanoparticle properties for clinical imaging.
- Integration of various imaging modalities including PET, SPECT, CT, MRI, optical, and ultrasound.
Main Results:
- Multifunctional nanoparticles enable complementary data acquisition from diverse imaging techniques.
- Hybrid imaging provides a more complete dataset for tumor characterization.
Conclusions:
- Nanoparticle-based multimodal imaging represents a significant advancement in nanomedicine.
- This technology enhances diagnostic accuracy and opens avenues for integrated cancer theranosis.
