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Updated: Mar 12, 2026
Multimodality Diagnosis of Mesenteric Ischemia
Published on: July 21, 2023
Could Mean Platelet Volume Be a Reliable Indicator for Acute Mesenteric Ischemia Diagnosis? A Case-Control Study
Vermi Degerli1, Isil Ergin2, Fulya Yilmaz Duran3
1Department of Emergency Medicine, Izmir Bozyaka Training and Research Hospital, Bozyaka, Izmir, Turkey.
Abstract:
Objective. Acute mesenteric ischemia (AMI) is a disease, usually seen in elderly people and accompanied by comorbid diseases. Mean platelet volume (MPV), the significant indicator of platelet activation and function, is associated with AMI. In this study, we considered that we can use MPV as a reliable indicator in the diagnosis of AMI. Methods. This study was conducted among AMI patients with two control groups. Age, gender, MPV, platelet count, concomitant diseases, abdominal computed tomography, and patient outcomes were recorded for evaluation. Control group I contained 41 healthy patients whose ages-genders were matched. Control group II contained 41 patients with no AMI, whose ages-genders-concomitant diseases were matched. Results. Of the total 41 AMI patients, 22 were female and 19 were male. The average age of them was 72.12 ± 13.2 (44-91) years. MPV was significantly increased in the AMI (p = 0.001) and control group II (p < 0.001) in comparison with healthy control groups. In the comparison of the AMI patients with their matched controls for concomitant diseases, no statistical difference was found in the MPV values. Conclusion. MPV may be used as an indicator of AMI only if the patient has no concomitant diseases. The existence of a concomitant disease brings into question the reliability of high MPV values as a suitable indicator.
Insights
Mean platelet volume (MPV) may indicate acute mesenteric ischemia (AMI) in patients without other health conditions. However, comorbidities can affect MPV reliability, making it a less dependable diagnostic marker in complex cases.
Area of Science:
- Vascular Surgery
- Hematology
- Diagnostic Markers
Background:
- Acute mesenteric ischemia (AMI) is a critical condition often affecting elderly patients with comorbidities.
- Mean platelet volume (MPV) is a recognized indicator of platelet activation and function.
- Previous research suggests a correlation between MPV and AMI.
Purpose of the Study:
- To evaluate the potential of MPV as a reliable diagnostic indicator for AMI.
- To investigate the influence of concomitant diseases on MPV levels in AMI patients.
Main Methods:
- A comparative study involving 41 AMI patients and two control groups (41 healthy individuals, 41 patients without AMI matched for age, gender, and comorbidities).
- Data collected included age, gender, MPV, platelet count, comorbidities, CT findings, and patient outcomes.
- Statistical analysis was performed to compare MPV values across groups.
Main Results:
- MPV was significantly elevated in AMI patients and the non-AMI control group compared to healthy controls (p < 0.001).
- No significant difference in MPV was observed between AMI patients and their matched controls when comorbidities were considered.
- MPV values were significantly higher in the AMI group (p = 0.001) compared to healthy controls.
Conclusions:
- MPV could serve as a diagnostic indicator for AMI, but its reliability is compromised by the presence of concomitant diseases.
- High MPV values in patients with comorbidities may not be solely attributable to AMI, questioning its diagnostic utility in such cases.
