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Epigenetic transcriptional memory.

Agustina D'Urso1, Jason H Brickner2

  • 1Department of Molecular Biosciences, Northwestern University, Evanston, IL, 60208, USA.

Current Genetics
|November 4, 2016
PubMed
Summary
This summary is machine-generated.

Organisms can develop epigenetic transcriptional memory, allowing faster adaptation to prior environmental conditions. This memory involves chromatin changes and poised RNA polymerase II binding for quicker gene reactivation.

Keywords:
ChromatinEnvironmental responseEpigeneticsHistone methylationMediatorMemoryNuclear pore complexTranscriptionTranscription factor

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Area of Science:

  • Molecular Biology
  • Genetics
  • Epigenetics

Background:

  • Organisms adapt gene expression to environmental changes like temperature, nutrients, and stress.
  • Some organisms exhibit
  • transcriptional memory
  • enabling more rapid future adaptation to previous conditions.
  • Epigenetic transcriptional memory involves heritable changes in gene expression patterns following a prior stimulus.

Purpose of the Study:

  • To discuss epigenetic transcriptional memory across different biological systems.
  • To review the current understanding of the molecular basis of transcriptional memory.
  • To present findings on the initiation and molecular mechanisms of transcriptional memory.

Main Methods:

  • Review of existing literature on epigenetic transcriptional memory.
  • Analysis of a well-characterized model system for transcriptional memory.
  • Investigation of chromatin structure and RNA polymerase II binding dynamics.

Main Results:

  • Epigenetic transcriptional memory is conserved from yeast to humans, involving chromatin modifications.
  • Memory initiation is triggered by transcription factor binding.
  • This binding induces chromatin structure changes, facilitating the recruitment of a poised RNA polymerase II (RNAPII).
  • Poised RNAPII binding accelerates future gene reactivation.

Conclusions:

  • Epigenetic transcriptional memory is a conserved mechanism for rapid environmental adaptation.
  • The process relies on transcription factor-mediated chromatin remodeling and poised RNAPII recruitment.
  • Understanding this memory mechanism provides insights into cellular adaptability and gene regulation.