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Updated: Mar 12, 2026

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Human ex-vivo oral tissue imaging using spectral domain polarization sensitive optical coherence tomography
Priyanka Sharma1,2, Yogesh Verma3,4, Khageswar Sahu3
1Laser Biomedical Applications Section, Raja Ramanna Centre for Advanced Technology, Indore, 452013, India. priyanka@rrcat.gov.in.
Abstract:
We report the use of spectral domain polarization sensitive optical coherence tomography for ex-vivo imaging of human oral mandibular tissue samples. Our results show that compared to the changes observed in the epithelium thickness and the decay constant of A-scan intensity profile, a much larger degree of change was observed in the phase retardation for tissue sites progressing from normal to the malignant state. These results suggest that monitoring of tissue retardance can help in better differentiation of normal and cancerous oral tissue sites.
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