Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

8.0K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
8.0K
Metastasis02:30

Metastasis

6.7K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.7K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

7.7K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.7K
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

9.6K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
9.6K
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

3.8K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

To the Maximal Nuclear Diameter and Cell Cycle Phase of Lymphoblasts or Myeloblasts in Patients Suffering from Acute Lymphoblastic and Myeloblastic Leukaemia. A Simple Morphological and Technical Note.

Folia biologica·2026
Same author

Novel soluble bazedoxifene formulation gains antiproliferative and migrastatic effect in squamous cell carcinoma cells.

Scientific reports·2026
Same author

Differential Expression of P-Element-Induced Wimpy Testis (PIWI)-Interacting RNAs in Glioblastoma Stem Cells Affects Their Biological Features: Implications for Tumor Progression and Patient Survival.

Laboratory investigation; a journal of technical methods and pathology·2026
Same author

Cold, Hot, and Lethal-The Tumour Microenvironment and the Immunology of Head and Neck Squamous Cell Carcinoma.

International journal of molecular sciences·2025
Same author

Gamma smooth muscle actin as a new potential marker of cancer-associated fibroblasts.

Histochemistry and cell biology·2025
Same author

The HOX code of human adult fibroblasts reflects their ectomesenchymal or mesodermal origin.

Histochemistry and cell biology·2025

Related Experiment Video

Updated: Mar 12, 2026

Author Spotlight: Assessing the Potential of Circulating Tumor Cells in Leptomeningeal Disease Research
06:25

Author Spotlight: Assessing the Potential of Circulating Tumor Cells in Leptomeningeal Disease Research

Published on: March 29, 2024

1.7K

Intercellular crosstalk in human malignant melanoma.

Barbora Dvořánková1,2, Pavol Szabo1,2, Ondřej Kodet1,2,3

  • 1Institute of Anatomy, Charles University, 1st Faculty of Medicine, U Nemocnice 3, 128 00, Prague, Czech Republic.

Protoplasma
|November 4, 2016
PubMed
Summary

Malignant melanoma incidence is rising globally. Research highlights the crucial role of the tumor microenvironment and intercellular communication in melanoma progression, suggesting new therapeutic strategies.

Keywords:
Cancer-associated fibroblastCytokineKeratinocyteMelanocyteMelanoma cellsMelanoma ecosystem

More Related Videos

Dual Effects of Melanoma Cell-derived Factors on Bone Marrow Adipocytes Differentiation
07:00

Dual Effects of Melanoma Cell-derived Factors on Bone Marrow Adipocytes Differentiation

Published on: August 23, 2018

6.6K
A Novel Stromal Fibroblast-Modulated 3D Tumor Spheroid Model for Studying Tumor-Stroma Interaction and Drug Discovery
07:20

A Novel Stromal Fibroblast-Modulated 3D Tumor Spheroid Model for Studying Tumor-Stroma Interaction and Drug Discovery

Published on: February 28, 2020

10.5K

Related Experiment Videos

Last Updated: Mar 12, 2026

Author Spotlight: Assessing the Potential of Circulating Tumor Cells in Leptomeningeal Disease Research
06:25

Author Spotlight: Assessing the Potential of Circulating Tumor Cells in Leptomeningeal Disease Research

Published on: March 29, 2024

1.7K
Dual Effects of Melanoma Cell-derived Factors on Bone Marrow Adipocytes Differentiation
07:00

Dual Effects of Melanoma Cell-derived Factors on Bone Marrow Adipocytes Differentiation

Published on: August 23, 2018

6.6K
A Novel Stromal Fibroblast-Modulated 3D Tumor Spheroid Model for Studying Tumor-Stroma Interaction and Drug Discovery
07:20

A Novel Stromal Fibroblast-Modulated 3D Tumor Spheroid Model for Studying Tumor-Stroma Interaction and Drug Discovery

Published on: February 28, 2020

10.5K

Area of Science:

  • Oncology
  • Developmental Biology
  • Cancer Research

Background:

  • Malignant melanoma incidence is increasing worldwide, with limited therapeutic options for advanced stages.
  • Melanoma cells, originating from neural crest-derived melanocytes, exhibit metastatic potential.
  • Tumor microenvironment significantly influences melanoma progression and malignancy.

Purpose of the Study:

  • To review strategies for modifying intercellular crosstalk in melanoma.
  • To explore therapeutic applications targeting melanoma microenvironment.

Main Methods:

  • Review of existing research on melanoma biology and microenvironment.
  • Analysis of the relationship between melanoma cells, melanocytes, and neural crest stem cells.
  • Exploration of intercellular communication pathways in melanoma.

Main Results:

  • Melanoma cells utilize neural crest migratory pathways, indicating microenvironmental influence.
  • Microenvironmental reprogramming can enhance melanoma cell malignancy.
  • Intercellular crosstalk is a key factor in melanoma ecosystems.

Conclusions:

  • Modifying intercellular crosstalk presents a promising therapeutic avenue for melanoma.
  • Targeting the tumor microenvironment is crucial for effective melanoma treatment.
  • Understanding melanoma cell-environment interactions is vital for developing novel therapies.