A permanent dopamine receptor up-regulation in the ovariectomized rat

Although a permanent supersensitivity to dopamine agonists can be induced by lesions of the nigrostriatal dopamine tract, the ovariectomized rat is the first animal model of a permanent hypersensitivity to dopamine agonists in which the neurons survive. This permanent behavioral hypersensitivity to direct acting dopamine agonists is accompanied by an increase in D2 dopamine receptor density in the striatum.