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Updated: Jul 21, 2026

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

Published on: May 5, 2014

Process Chemistry in Antiviral Research.

Yong-Li Zhong¹, Nobuyoshi Yasuda², Hongming Li²

¹Department of Process Chemistry, Merck and Co., Inc., PO Box 2000, Rahway, NJ, 07065, USA. yongli_zhong@merck.com.

Topics in Current Chemistry (Cham)

|November 4, 2016

Summary

This review highlights process chemistry innovations for recent antiviral drugs. It details practical syntheses for Hepatitis C, HIV, and influenza treatments, enabling wider patient access.

Keywords:

Antivirals Asymmetric synthesis Darunavir Elbasvir Grazoprevir HCV HIV Influenza Peramivir Practical synthesis Process chemistry Sofosbuvir

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Area of Science:

Medicinal Chemistry
Organic Synthesis
Pharmaceutical Development

Background:

Antiviral therapies are crucial for managing infectious diseases.
The last decade has seen significant advancements in antiviral drug development.
Process chemistry plays a vital role in making new drugs accessible.

Purpose of the Study:

To review antiviral therapies approved in the last decade.
To focus on the process chemistry enabling the synthesis of these drugs.
To present practical synthesis highlights for key antiviral medications.

Main Methods:

Review of scientific literature on recently approved antiviral drugs.
Analysis of process chemistry strategies for selected drug syntheses.
Highlighting key synthetic steps and challenges overcome.

Main Results:

Detailed process chemistry insights for Hepatitis C virus (HCV) drugs: sofosbuvir, grazoprevir, and elbasvir.
Discussion of the practical synthesis of human immunodeficiency virus (HIV) therapy: darunavir.
Presentation of the synthesis highlights for influenza treatment: peramivir.

Conclusions:

Process chemistry advancements have been instrumental in the successful development and accessibility of novel antiviral agents.
The presented case studies demonstrate efficient and scalable synthetic routes for critical antiviral medications.
Continued innovation in process chemistry is essential for future antiviral drug discovery and manufacturing.