Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

A 9-year retrospective mortality review of captive orange-bellied parrots (Neophema chrysogaster) in Australia.

Australian veterinary journal·2026
Same author

Novel phylogenomic and biogeographic insights into Palaquium and tribe Isonandreae (Sapotaceae).

Molecular phylogenetics and evolution·2025
Same author

Analysis insights to support the use of wastewater and environmental surveillance data for infectious diseases and pandemic preparedness.

Epidemics·2025
Same author

African swine fever: advances and challenges.

Revue scientifique et technique (International Office of Epizootics)·2024
Same author

The value of virtual biobanks for transparency purposes with respect to reagents and samples used during test development and validation.

Revue scientifique et technique (International Office of Epizootics)·2021
Same author

Neuronal inclusions resembling Negri bodies in the thalamus of a red kangaroo (Macropus rufus).

Australian veterinary journal·2021

Related Experiment Video

Updated: Mar 12, 2026

Clinical Examination Protocol to Detect Atypical and Classical Scrapie in Sheep
13:42

Clinical Examination Protocol to Detect Atypical and Classical Scrapie in Sheep

Published on: January 19, 2014

14.2K

Atypical scrapie in Australia.

R W Cook1, J Bingham2, A S Besier3

  • 1Regional Veterinary Laboratory, NSW Department of Primary Industries, Wollongbar, New South Wales 2480, Australia.

Australian Veterinary Journal
|November 4, 2016
PubMed
Summary
This summary is machine-generated.

Atypical scrapie, a neurological disease in sheep, has been diagnosed in Australia. Histological examination of the brain, particularly the cerebellum, is crucial for identifying this condition.

Keywords:
atypical scrapieprion diseasesheeptransmissible spongiform encephalopathy

More Related Videos

Procedures for Identifying Infectious Prions After Passage Through the Digestive System of an Avian Species
12:00

Procedures for Identifying Infectious Prions After Passage Through the Digestive System of an Avian Species

Published on: November 6, 2013

11.7K
Monitoring Immune Cells Trafficking Fluorescent Prion Rods Hours after Intraperitoneal Infection
09:22

Monitoring Immune Cells Trafficking Fluorescent Prion Rods Hours after Intraperitoneal Infection

Published on: November 19, 2010

11.9K

Related Experiment Videos

Last Updated: Mar 12, 2026

Clinical Examination Protocol to Detect Atypical and Classical Scrapie in Sheep
13:42

Clinical Examination Protocol to Detect Atypical and Classical Scrapie in Sheep

Published on: January 19, 2014

14.2K
Procedures for Identifying Infectious Prions After Passage Through the Digestive System of an Avian Species
12:00

Procedures for Identifying Infectious Prions After Passage Through the Digestive System of an Avian Species

Published on: November 6, 2013

11.7K
Monitoring Immune Cells Trafficking Fluorescent Prion Rods Hours after Intraperitoneal Infection
09:22

Monitoring Immune Cells Trafficking Fluorescent Prion Rods Hours after Intraperitoneal Infection

Published on: November 19, 2010

11.9K

Area of Science:

  • Veterinary Neurology
  • Prion Diseases
  • Sheep Pathology

Background:

  • Atypical scrapie (Nor98) emerged in Norway in 1998 and has since spread globally.
  • This disease affects sheep, including in regions previously considered free of classical scrapie.
  • Recent diagnoses in Australia indicate its continued international prevalence.

Purpose of the Study:

  • To report the first cases of atypical scrapie diagnosed in Australia.
  • To describe the neuropathological features of atypical scrapie in affected sheep.
  • To emphasize the diagnostic significance of specific brain lesions.

Main Methods:

  • Neurological examination of five affected sheep (four Merino, one Merino-cross).
  • Histopathological analysis of brain tissue, focusing on grey matter vacuolation (spongiform change).
  • Immunohistochemical detection of abnormal prion protein (PrPSc) in grey and white matter.

Main Results:

  • Diagnosis confirmed by spongiform change in the cerebellar molecular layer and PrPSc deposition.
  • Lesions were distinct from classical scrapie, with minimal changes in the caudal brainstem.
  • A unique lesion profile was observed in the affected sheep.

Conclusions:

  • The characteristic lesion profile of atypical scrapie necessitates careful histological evaluation.
  • Routine examination of the cerebellum for neuropil vacuolation and PrPSc is vital for diagnosing neurological disease in sheep.
  • This study underscores the importance of recognizing atypical scrapie's distinct pathological features.