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Unruptured intracranial aneurysms: development, rupture and preventive management
Nima Etminan1, Gabriel J Rinkel2
1Department of Neurosurgery, University Hospital Mannheim, Theodor-Kutzer-Ufer 1-3, Medical Faculty, University of Heidelberg, 68167 Mannheim, Germany.
Nature Reviews. Neurology
|November 4, 2016
Summary
Unruptured intracranial aneurysms (UIAs) are common and increasingly detected. This review synthesizes data on UIA management, focusing on rupture risk, treatment efficacy, and clinical guidance for incidental findings.
Area of Science:
- Neurology
- Radiology
- Vascular Surgery
Background:
- Saccular unruptured intracranial aneurysms (UIAs) affect 3% of adults, with increasing detection due to advanced neuroimaging.
- While data on aneurysm development and rupture exist, information on preventive treatment risks and efficacy is limited.
Purpose of the Study:
- To review current human data on intracranial aneurysm formation, progression, and rupture.
- To analyze the risks and efficacy of preventive treatments for UIAs.
- To provide clinical management guidance for incidentally detected UIAs.
Main Methods:
- Literature review of human data on intracranial aneurysms.
- Analysis of evidence regarding aneurysm development, progression, and rupture.
- Evaluation of risks and benefits of preventive treatment strategies.
Main Results:
- Highlights latest human data on intracranial aneurysm natural history.
- Discusses risks associated with preventive treatment, influencing clinical decisions.
- Explores novel radiological surrogates for rupture risk assessment.
Conclusions:
- Clinical management of UIAs requires balancing patient factors, rupture risk, and treatment complications.
- Future research should address pivotal questions arising from current UIA data.
- Provides guidance for managing incidentally detected unruptured intracranial aneurysms.
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