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Chronic intracerebral cannula can affect feeding behavior in the rat
C Larue-Achagiotis1, J Louis-Sylvestre
1Laboratoire de Neurobiologie de la Nutrition, Université Pierre et Marie Curie, Paris, France.
Abstract:
Intracerebral cannulae were placed in the lateral ventricle of rats. It was shown that the cannulae per se can affect feeding behavior. After recovery from surgery, rats displayed an unusual eating rate which consisted of very long, slow and large meals. This slow eating rate led to a modification of the circadian pattern; it induced a decrease in night-time and increase in day-time cumulative intakes. This phenomenon appeared when cannulae crossed the cortical motor area concerned with forelimb movements. Different stereotaxic coordinates had to be used in order to place cannulae in the lateral ventricle without disturbing the feeding pattern. This observation underlines the importance of recording feeding pattern before any surgery in any study of feeding behavior.