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The Abscission Checkpoint: Making It to the Final Cut.

Viola Nähse¹, Liliane Christ¹, Harald Stenmark²

¹Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, 0379 Oslo, Norway; Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, 0379 Oslo, Norway.

Trends in Cell Biology

|November 5, 2016

Summary

The abscission checkpoint delays cell division completion until daughter cells are fully separated. This study proposes a molecular framework for how this critical cell division checkpoint operates.

Keywords:

Aurora B ESCRT-III NoCut chromatin bridge cytokinesis genome instability membrane scission

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Area of Science:

Cell Biology
Molecular Biology
Genetics

Background:

Cytokinesis, the final stage of cell division, involves abscission to separate daughter cells.
The abscission checkpoint ensures proper cell separation by delaying abscission when errors are detected.
Known triggers for the abscission checkpoint include persistent chromatin, high membrane tension, nuclear pore defects, and DNA replication stress.

Purpose of the Study:

To propose a molecular framework for abscission checkpoint signaling.
To discuss the function and physiological relevance of the abscission checkpoint.

Main Methods:

Literature review and synthesis of existing research on the abscission checkpoint.
Theoretical modeling of molecular interactions within the abscission checkpoint pathway.

Main Results:

A molecular framework for abscission checkpoint signaling is proposed, integrating known inputs.
The framework highlights the central role of Aurora B protein kinase activity.

Conclusions:

The proposed framework provides a basis for understanding abscission checkpoint regulation.
Further research is needed to elucidate the precise molecular mechanisms and physiological significance of this checkpoint.