Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Blood-brain Barrier

The Blood-brain Barrier

Inflammation

Inflammation

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Evaluating the effectiveness of simvastatin in slowing the progression of disability in secondary progressive multiple sclerosis: a synopsis of MS-STAT2, a multicentre, randomised controlled, double-blind, phase 3 clinical trial.

Health technology assessment (Winchester, England)·2026

Same author

Upgrade and Downgrade Rates of Fibroepithelial Lesions in a B3 Lesion Cohort: A 15-Year Analysis from a University Hospital.

The British journal of radiology·2026

Same author

Erythrocyte Fragility in Progressive Multiple Sclerosis.

European journal of neurology·2026

Same author

Psychometric properties of the Chinese version of the Subarachnoid Hemorrhage Outcomes Tool (SAHOT) in elderly SAH patients.

BMC geriatrics·2026

Same author

A novel approach to characterize the energy cost of human cool-seeking behavior and its individual variability during heat stress.

American journal of physiology. Regulatory, integrative and comparative physiology·2026

Same author

Sirolimus-Coated Versus Paclitaxel-Coated Balloons for Coronary Artery Disease: A Grade Assessed Systematic Review and Meta-Analysis.

Critical pathways in cardiology·2026

Search research articles

Related Experiment Video

Updated: Mar 12, 2026

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

Published on: March 26, 2019

The effect of systemic inflammation on human brain barrier function.

Elliot Elwood¹, Zhi Lim¹, Hammad Naveed¹

¹Clinical Neurosciences, Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

Brain, Behavior, and Immunity

|November 5, 2016

Summary

Systemic inflammation impacts the blood-brain barrier (BBB) function, particularly when cerebrospinal fluid (CSF) abnormalities are present. C-reactive protein is a key inflammatory marker affecting BBB integrity.

Keywords:

Albumin Blood-brain barrier Cerebrospinal fluid Infection Inflammation Systemic

More Related Videos

Analyzing the Permeability of the Blood-Brain Barrier by Microbial Traversal through Microvascular Endothelial Cells

Analyzing the Permeability of the Blood-Brain Barrier by Microbial Traversal through Microvascular Endothelial Cells

Published on: February 14, 2020

Author Spotlight: Studying Brain Endothelial Barrier in Metastatic Cancer Using Impedance-Based Biosensors

Author Spotlight: Studying Brain Endothelial Barrier in Metastatic Cancer Using Impedance-Based Biosensors

Published on: September 22, 2023

Related Experiment Videos

Last Updated: Mar 12, 2026

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

Published on: March 26, 2019

Analyzing the Permeability of the Blood-Brain Barrier by Microbial Traversal through Microvascular Endothelial Cells

Analyzing the Permeability of the Blood-Brain Barrier by Microbial Traversal through Microvascular Endothelial Cells

Published on: February 14, 2020

Author Spotlight: Studying Brain Endothelial Barrier in Metastatic Cancer Using Impedance-Based Biosensors

Author Spotlight: Studying Brain Endothelial Barrier in Metastatic Cancer Using Impedance-Based Biosensors

Published on: September 22, 2023

Area of Science:

Neuroscience
Immunology
Neurology

Background:

The blood-brain barrier (BBB) is crucial for neurological health, regulating substance passage into the brain.
Systemic inflammation is increasingly recognized as a factor influencing BBB integrity.
Previous research suggests a link between systemic inflammation and impaired BBB function.

Purpose of the Study:

To investigate the association between systemic inflammatory markers and blood-brain barrier function.
To determine if systemic inflammation affects BBB integrity in patients with and without cerebrospinal fluid (CSF) abnormalities.

Main Methods:

Analysis of 1273 consecutive lumbar punctures.
Measurement of systemic inflammatory markers: leucocytes, erythrocyte sedimentation rate, and C-reactive protein.
Assessment of BBB function using the cerebrospinal fluid (CSF)/serum albumin ratio.

Main Results:

Systemic inflammation did not significantly alter the CSF/serum albumin ratio in the absence of CSF abnormalities.
In the presence of CSF abnormalities, systemic inflammation significantly predicted the CSF/serum albumin ratio.
C-reactive protein was identified as the primary systemic inflammatory marker driving this effect, with temporal analysis suggesting causality.

Conclusions:

A diseased blood-brain barrier exhibits heightened susceptibility to systemic inflammation.
C-reactive protein is a significant predictor of BBB dysfunction during systemic inflammation when CSF abnormalities are present.
These findings highlight the intricate relationship between systemic inflammatory conditions and neurological integrity.