Noncoding RNAs in the development, diagnosis, and prognosis of colorectal cancer

Area of Science:

• Genomics
• Molecular Biology
• Oncology

Background:

• The human genome is largely transcribed into noncoding RNA (ncRNA), which plays vital roles in biological processes.
• Dysregulation of ncRNA is implicated in various diseases, notably cancer.
• ncRNA's involvement in gene expression regulation is increasingly recognized.

Purpose of the Study:

• To review the functions and mechanisms of various ncRNAs in colorectal cancer (CRC) progression.
• To explore the clinical applications of ncRNAs in CRC diagnosis and prognosis.
• To consolidate current knowledge on ncRNA in CRC for future research.

Main Methods:

• Literature review of ncRNA functions in CRC.
• Analysis of ncRNA mechanisms in gene expression.
• Examination of clinical applications of ncRNAs in CRC diagnosis and prognosis.

Main Results:

• ncRNAs, including miRNA, lincRNA, snoRNA, circRNA, and pseudogene RNA, are integral to CRC development.
• These ncRNAs influence gene expression directly or indirectly.
• Clinical applications for ncRNAs in CRC diagnosis and prognosis are emerging.

Conclusions:

• ncRNAs are key players in the initiation and progression of colorectal cancer.
• Understanding ncRNA roles provides insights into CRC pathogenesis.
• ncRNAs represent promising novel biomarkers and therapeutic targets for CRC.