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The effect of endotoxin on nociception in mice
M Ishikawa1, S Sugawara, Y Takayanagi
1Department of Toxicology and Pharmacology, Cancer Research Institute, Tohoku College of Pharmacy, Sendai, Japan.
Research Communications in Chemical Pathology and Pharmacology
|July 1, 1989
Abstract:
The possible antinociceptive activity of endotoxin was studied in mice. The antinociceptive properties of endotoxin (0.0003, 0.003, 0.03, 0.3 and 3 mg/kg, i.p.) were evaluated using the phenylbenzoquinone-induced writhing test. The antinociceptive activity of endotoxin was more potent than that of aminopyrine and morphine.