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ROS homeostasis and metabolism: a critical liaison for cancer therapy
Jongdoo Kim1, Jaehong Kim2,3, Jong-Sup Bae4
1Cancer Control Team, Gachon University Gil Medical Center, Incheon, Republic of Korea.
Abstract:
Evidence indicates that hypoxia and oxidative stress can control metabolic reprogramming of cancer cells and other cells in tumor microenvironments and that the reprogrammed metabolic pathways in cancer tissue can also alter the redox balance. Thus, important steps toward developing novel cancer therapy approaches would be to identify and modulate critical biochemical nodes that are deregulated in cancer metabolism and determine if the therapeutic efficiency can be influenced by changes in redox homeostasis in cancer tissues. In this review, we will explore the molecular mechanisms responsible for the metabolic reprogramming of tumor microenvironments, the functional modulation of which may disrupt the effects of or may be disrupted by redox homeostasis modulating cancer therapy.
Insights
Hypoxia and oxidative stress reprogram cancer cell metabolism, altering tumor microenvironments and redox balance. Targeting these metabolic nodes may offer novel cancer therapy strategies by influencing redox homeostasis.
Area of Science:
- Oncology
- Cancer Metabolism
- Redox Biology
Background:
- Hypoxia and oxidative stress are key regulators of metabolic reprogramming in cancer cells and tumor microenvironments.
- Metabolic reprogramming in cancer tissues significantly impacts cellular redox balance.
- Understanding these interactions is crucial for developing effective cancer therapies.
Purpose of the Study:
- To explore the molecular mechanisms driving metabolic reprogramming in tumor microenvironments.
- To investigate how modulating these metabolic pathways affects cancer therapy.
- To determine the role of redox homeostasis in the efficacy of cancer treatments.
Main Methods:
- Review of molecular mechanisms underlying metabolic reprogramming in tumors.
- Analysis of the interplay between metabolic pathways and redox balance.
- Exploration of therapeutic strategies targeting metabolic nodes and redox homeostasis.
Main Results:
- Metabolic reprogramming is intricately linked to hypoxia and oxidative stress in tumors.
- Altered metabolic pathways in cancer can disrupt or be disrupted by redox homeostasis.
- Targeting deregulated metabolic nodes holds potential for novel cancer therapies.
Conclusions:
- Modulating metabolic reprogramming in tumor microenvironments is a promising therapeutic avenue.
- The interplay between cancer metabolism and redox homeostasis is critical for treatment outcomes.
- Further research into these mechanisms could lead to more effective cancer treatments.
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