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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Related Experiment Video

Updated: Mar 12, 2026

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
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Can a diabetic foot be malignant?

Muhammad Shoaib Zaidi1, Asim Hassan2, Samir Ouizi3

  • 1University Diabetes Center, King Abdul Aziz University Hospital, Riyadh, Saudi Arabia.

JPMA. the Journal of the Pakistan Medical Association
|November 5, 2016
PubMed
Summary
This summary is machine-generated.

Diabetes is associated with various cancers, including melanoma. This case study highlights a diabetic patient whose non-healing foot ulcer was diagnosed as invasive malignant melanoma.

Keywords:
Diabetes, Diabetic foot ulcer (DFU), Melanoma.

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Area of Science:

  • Oncology
  • Endocrinology
  • Dermatology

Background:

  • Diabetes mellitus is a known risk factor for several malignancies.
  • Malignant melanoma is a rare but serious complication that can arise in diabetic patients.
  • Diabetic foot ulcers are common and can sometimes mask underlying pathologies.

Observation:

  • An elderly male patient with Type 2 diabetes presented with a chronic, non-healing wound on his right heel.
  • The wound's persistent nature prompted further investigation beyond typical diabetic foot complications.

Findings:

  • Histopathological examination revealed the non-healing ulcer to be an invasive malignant melanoma.
  • This case underscores the importance of considering rare diagnoses in diabetic foot wounds.

Implications:

  • Clinicians should maintain a high index of suspicion for melanoma in diabetic patients with non-healing foot ulcers.
  • Early detection and diagnosis of melanoma in this population can improve patient outcomes.
  • Further research may elucidate the specific mechanisms linking diabetes and melanoma development in foot ulcers.